MolNFT v1 · #472392 · protein
AlphaFold monomer V2.0 prediction for thrombomodulin (P07204)
P07204: “AlphaFold monomer V2.0 prediction for thrombomodulin (P07204)”. 2 pockets (best druggability 0.41). MolNFT v1 #472392 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- P07204
- Type
- protein
- Length
- 575 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0xbDA05C32aD6eE153C8C5A78dfa48d7Ba25694fea
- Molecule
- Thrombomodulin
- UniProt
- P07204
- Pockets
- 2 · best druggability 0.41
Structure
1 distinct chain · 13% helix, 29% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Thrombomodulin | protein | 575 | 13% helix, 29% strand | P07204 |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 93 | 0.41 | 0.78 | 17 | empty |
| 2 | 72 | 0.29 | 0.73 | 20 | empty |
Modifications
Observed in the structure: 23 disulfide (disulfide).
Compared structures
- 7T4R · CryoEM structure of the HCMV Pentamer gH/gL/UL128/UL130/UL131A in complex with THBD and… · an experimental structure of the same protein · chain A against A, TM-score 0.24
- 7T4R · Cryoem structure of the hcmv pentamer GH/GL/UL128/UL130/UL131A in complex with thbd and… · an experimental structure of the same protein · chain A against A, TM-score 0.24
- 1DX5 · Crystal structure of the thrombin-thrombomodulin complex · an experimental structure of the same protein · chain A against J, TM-score 0.19
- 1DX5 · Crystal structure of the thrombin-thrombomodulin complex · an experimental structure of the same protein · chain A against I, TM-score 0.19
- 5TO3 · Crystal structure of thrombin mutant W215A/E217A fused to EGF456 of thrombomodulin via a… · an experimental structure of the same protein · chain A against B, TM-score 0.19
- 5TO3 · Crystal structure of thrombin mutant W215A/E217A fused to EGF456 of thrombomodulin via a… · an experimental structure of the same protein · chain A against B, TM-score 0.18
- 3GIS · Crystal structure of na-free thrombin in complex with thrombomodulin · an experimental structure of the same protein · chain A against X, TM-score 0.18
- 3GIS · Crystal Structure of Na-free Thrombin in Complex with Thrombomodulin · an experimental structure of the same protein · chain A against X, TM-score 0.18
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P07204
- Elsewhere: UniProt P07204 · AlphaFold DB P07204
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