UniProt P07204
Thrombomodulin (P07204)
Thrombomodulin (UniProt P07204): 25 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 6 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P07204
- Protein
- Thrombomodulin
- Experimental structures
- 25
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 6 · 1 record with a druggable one
Structures
26 records of P07204 in the MolNFT archive: 25 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1ADX | Fifth EGF-like domain of thrombomodulin (TMEGF5), NMR, 14 structures | solution nmr | A | — | — |
| 1ADX | Fifth EGF-like domain of thrombomodulin (TMEGF5), NMR, 14 structures | solution nmr | A | — | — |
| 1DQB | NMR structure of thrombomodulin EGF(4-5) | solution nmr | A | — | — |
| 1DQB | NMR structure of thrombomodulin EGF(4-5) | solution nmr | A | — | — |
| 1DX5 | Crystal structure of the thrombin-thrombomodulin complex | x-ray diffraction | I, J, K, L | — | — |
| 1DX5 | Crystal structure of the thrombin-thrombomodulin complex | x-ray diffraction | I, J, K, L | — | — |
| 1EGT | Thrombin-bound structure of an EGF subdomain from human thrombomodulin determined by transferred… | solution nmr | A | — | — |
| 1EGT | Thrombin-bound structure of an EGF subdomain from human thrombomodulin determined by transferred… | solution nmr | A | — | — |
| 1FGD | Epidermal growth factor (EGF) subdomain of human thrombomodulin (NMR, 11 structures) | solution nmr | A | — | — |
| 1FGD | Epidermal growth factor (EGF) subdomain of human thrombomodulin (NMR, 11 structures) | solution nmr | A | — | — |
| 1FGE | Epidermal growth factor (EGF) subdomain of human thrombomodulin (NMR, 14 structures) | solution nmr | A | — | — |
| 1FGE | Epidermal growth factor (EGF) subdomain of human thrombomodulin (NMR, 14 structures) | solution nmr | A | — | — |
| 1HLT | The structure of a nonadecapeptide of the fifth EGF domain of thrombomodulin complexed with thrombin | x-ray diffraction | R | — | — |
| 1HLT | The structure of a nonadecapeptide of the fifth EGF domain of thrombomodulin complexed with thrombin | x-ray diffraction | R | — | — |
| 1TMR | The structure of a 19 residue fragment from the C-loop of the fourth epidermal growth factor-like… | solution nmr | A | — | — |
| 1TMR | The structure of a 19 residue fragment from the C-loop of the fourth epidermal growth factor-like… | solution nmr | A | — | — |
| 1ZAQ | Fourth EGF-like domain of thrombomodulin, NMR, 12 structures | solution nmr | A | — | — |
| 1ZAQ | Fourth EGF-like domain of thrombomodulin, NMR, 12 structures | solution nmr | A | — | — |
| 2ADX | Fifth EGF-like domain of thrombomodulin (TMEGF5), NMR, minimized average structure | solution nmr | A | — | — |
| 2ADX | Fifth EGF-like domain of thrombomodulin (TMEGF5), NMR, minimized average structure | solution nmr | A | — | — |
| 3GIS | Crystal Structure of Na-free Thrombin in Complex with Thrombomodulin | x-ray diffraction | X, Y, Z | — | — |
| 3GIS | Crystal structure of na-free thrombin in complex with thrombomodulin | x-ray diffraction | X, Y, Z | — | — |
| 5TO3 | Crystal structure of thrombin mutant W215A/E217A fused to EGF456 of thrombomodulin via a 31-residue… | x-ray diffraction | B | NAG, K, NA | — |
| 7T4R | CryoEM structure of the HCMV Pentamer gH/gL/UL128/UL130/UL131A in complex with THBD and… | electron microscopy | A | — | 4 (best 0.79) |
| 7T4R | Cryoem structure of the hcmv pentamer GH/GL/UL128/UL130/UL131A in complex with thbd and… | electron microscopy | A | — | — |
| P07204 | AlphaFold monomer V2.0 prediction for thrombomodulin (P07204) | predicted | A | — | 2 (best 0.41) |
Ligands
Experiment against prediction
- 7T4R chain A against the predicted model P07204: TM-score 0.88, RMSD 2.30 Å
- 7T4R chain A against the predicted model P07204: TM-score 0.88, RMSD 2.30 Å
- 1DX5 chain I against the predicted model P07204: TM-score 0.83, RMSD 2.03 Å
- 1DX5 chain I against the predicted model P07204: TM-score 0.83, RMSD 2.03 Å
- 3GIS chain Z against the predicted model P07204: TM-score 0.82, RMSD 2.10 Å
- 3GIS chain Z against the predicted model P07204: TM-score 0.82, RMSD 2.10 Å
- 3GIS chain X against the predicted model P07204: TM-score 0.80, RMSD 2.23 Å
- 3GIS chain X against the predicted model P07204: TM-score 0.80, RMSD 2.23 Å
- 3GIS chain Y against the predicted model P07204: TM-score 0.71, RMSD 3.24 Å
- 3GIS chain Y against the predicted model P07204: TM-score 0.71, RMSD 3.24 Å
Elsewhere
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