MolNFT v1 · #469442 · protein
AlphaFold monomer V2.0 prediction for topoisomerase 1-associated factor 1 (P53840)
P53840: “AlphaFold monomer V2.0 prediction for topoisomerase 1-associated factor 1 (P53840)”. 11 pockets (best druggability 0.78). MolNFT v1 #469442 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- P53840
- Type
- protein
- Length
- 1,238 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x0E160a0b29352d1dFD5B4Ac9c87C2d4aaC49D916
- Molecule
- Topoisomerase 1-associated factor 1
- UniProt
- P53840
- Pockets
- 11 · best druggability 0.78
Structure
1 distinct chain · 54% helix, 3% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Topoisomerase 1-associated factor 1 | protein | 1238 | 54% helix, 3% strand | P53840 |
Pockets
11 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 843 | 0.78 | 0.81 | 60 | empty |
| 2 | 406 | 0.71 | 0.82 | 42 | empty |
| 3 | 290 | 0.59 | 0.78 | 35 | empty |
| 4 | 196 | 0.56 | 0.79 | 28 | empty |
| 5 | 277 | 0.52 | 0.74 | 22 | empty |
Compared structures
- 6SKL · Cryo-EM structure of the CMG Fork Protection Complex at a replication fork - Conformation… · an experimental structure of the same protein · chain A against X, TM-score 0.50
- 8B9B · S. cerevisiae replisome + Ctf4, bound by pol alpha. Complex engaged with a fork DNA… · an experimental structure of the same protein · chain A against X, TM-score 0.50
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P53840
- Elsewhere: UniProt P53840 · AlphaFold DB P53840
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