AlphaFold monomer V2.0 prediction for topoisomerase 1-associated factor 1 (P53840)

Structure

1 distinct chain · 54% helix, 3% strand (DSSP).

Pockets

11 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.

Compared structures

• 8XGC · Structure of yeast replisome associated with FACT and histone hexamer, Composite map · an experimental structure of the same protein · chain A against I, TM-score 0.55
• 7PMN · S. cerevisiae replisome-SCF(Dia2) complex bound to double-stranded DNA (conformation II) · an experimental structure of the same protein · chain A against X, TM-score 0.50
• 7PMK · S. cerevisiae replisome-SCF(Dia2) complex bound to double-stranded DNA (conformation I) · an experimental structure of the same protein · chain A against X, TM-score 0.50
• 6SKL · Cryo-EM structure of the CMG Fork Protection Complex at a replication fork - Conformation… · an experimental structure of the same protein · chain A against X, TM-score 0.50
• 8B9C · S. cerevisiae pol alpha - replisome complex · an experimental structure of the same protein · chain A against X, TM-score 0.50
• 8B9B · S. cerevisiae replisome + Ctf4, bound by pol alpha. Complex engaged with a fork DNA… · an experimental structure of the same protein · chain A against X, TM-score 0.50
• 8B9A · S. cerevisiae replisome + Ctf4, bound by pol alpha primase. Complex engaged with a fork… · an experimental structure of the same protein · chain A against X, TM-score 0.50
• 8KG6 · Yeast replisome in state I · an experimental structure of the same protein · chain A against K, TM-score 0.49

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P53840
• Elsewhere: UniProt P53840 · AlphaFold DB P53840