MolNFT v1 · #454031 · protein
AlphaFold monomer V2.0 prediction for synaptotagmin-1 (P21579)
P21579: “AlphaFold monomer V2.0 prediction for synaptotagmin-1 (P21579)”. 2 pockets (best druggability 0.40). MolNFT v1 #454031 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- P21579
- Type
- protein
- Length
- 422 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x58f53eCb168388AB0f1d3Cb9e5809dDe7f81eC02
- Molecule
- Synaptotagmin-1
- UniProt
- P21579
- Pockets
- 2 · best druggability 0.40
Structure
1 distinct chain · 20% helix, 31% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Synaptotagmin-1 | protein | 422 | 20% helix, 31% strand | P21579 |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 128 | 0.40 | 0.74 | 20 | empty |
| 2 | 50 | 0.32 | 0.78 | 19 | empty |
Compared structures
- 2R83 · Crystal structure analysis of human synaptotagmin 1 C2A-C2B · an experimental structure of the same protein · chain A against A, TM-score 0.37
- 2R83 · Crystal structure analysis of human synaptotagmin 1 C2A-C2B · an experimental structure of the same protein · chain A against A, TM-score 0.37
- 4V11 · Structure of Synaptotagmin-1 with SV2A peptide phosphorylated at Thr84 · an experimental structure of the same protein · chain A against A, TM-score 0.35
- 4V11 · Structure of synaptotagmin-1 with SV2A peptide phosphorylated at THR84 · an experimental structure of the same protein · chain A against A, TM-score 0.35
- 6U4W · 1.4 A structure of a pathogenic human Syt 1 C2B (D366E) · an experimental structure of the same protein · chain A against A, TM-score 0.35
- 6U4W · 1.4 a structure of a pathogenic human syt 1 C2B (D366E) · an experimental structure of the same protein · chain A against A, TM-score 0.35
- 6TZ3 · Crystal structure of human synaptotagmin 1 C2B without CA2+ · an experimental structure of the same protein · chain A against A, TM-score 0.35
- 6TZ3 · Crystal Structure of Human Synaptotagmin 1 C2B without Ca2+ · an experimental structure of the same protein · chain A against A, TM-score 0.35
- 6U4U · 1.3 A structure of a pathogenic human Syt 1 C2B (I368T) · an experimental structure of the same protein · chain A against A, TM-score 0.35
- 6U4U · 1.3 a structure of a pathogenic human syt 1 C2B (I368T) · an experimental structure of the same protein · chain A against A, TM-score 0.35
- 2N1T · Dynamic binding mode of a synaptotagmin-1-SNARE complex in solution · an experimental structure of the same protein · chain A against E, TM-score 0.35
- 2N1T · Dynamic binding mode of a synaptotagmin-1-snare complex in solution · an experimental structure of the same protein · chain A against E, TM-score 0.35
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P21579
- Elsewhere: UniProt P21579 · AlphaFold DB P21579
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