UniProt P21579
Synaptotagmin-1 (P21579)
Synaptotagmin-1 (UniProt P21579): 31 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 2 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P21579
- Protein
- Synaptotagmin-1
- Experimental structures
- 31
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 2 · 0 records with a druggable one
Structures
32 records of P21579 in the MolNFT archive: 31 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2K45 | C2A domain of synaptototagmin I solution structure in the FGF-1-C2A binary complex: key component… | solution nmr | A | — | — |
| 2K45 | C2A domain of synaptototagmin I solution structure in the FGF-1-C2A binary complex: key component… | solution nmr | A | — | — |
| 2K4A | FGF-1-C2A binary complex structure: a key component in the fibroblast growthfactor non-classical… | solution nmr | A | — | — |
| 2K4A | FGF-1-C2A binary complex structure: a key component in the fibroblast growthfactor non-classical… | solution nmr | A | — | — |
| 2KI6 | The FGF1-S100A13-C2A hetero-hexameric complex structure: A component in the non-classical pathway… | solution nmr | A, F | — | — |
| 2KI6 | The FGF1-S100A13-C2A hetero-hexameric complex structure: a component in the non-classical pathway… | solution nmr | A, F | — | — |
| 2LHA | Solution structure of C2B with IP6 | solution nmr | A | — | — |
| 2LHA | Solution structure of C2B with IP6 | solution nmr | A | — | — |
| 2N1T | Dynamic binding mode of a synaptotagmin-1-SNARE complex in solution | solution nmr | E | — | — |
| 2N1T | Dynamic binding mode of a synaptotagmin-1-snare complex in solution | solution nmr | E | — | — |
| 2R83 | Crystal structure analysis of human synaptotagmin 1 C2A-C2B | x-ray diffraction | A, B | — | — |
| 2R83 | Crystal structure analysis of human synaptotagmin 1 C2A-C2B | x-ray diffraction | A, B | — | — |
| 3F00 | Crystal Structure of Synaptotagmin I C2A domain with Cu(II) | x-ray diffraction | A | — | — |
| 3F00 | Crystal structure of synaptotagmin I C2A domain with CU(II) | x-ray diffraction | A | — | — |
| 3F01 | Crystal Structure of Synaptotagmin I C2A domain with Cu(II) | x-ray diffraction | A | — | — |
| 3F01 | Crystal structure of synaptotagmin I C2A domain with CU(II) | x-ray diffraction | A | — | — |
| 3F04 | Crystal Structure of Synaptotagmin I C2A domain | x-ray diffraction | A | — | — |
| 3F04 | Crystal structure of synaptotagmin I C2A domain | x-ray diffraction | A | — | — |
| 3F05 | Crystal Structure of Synaptotagmin I C2A domain with Mn(II) | x-ray diffraction | A | — | — |
| 3F05 | Crystal structure of synaptotagmin I C2A domain with MN(II) | x-ray diffraction | A | — | — |
| 4ISQ | Binding domain of Botulinum neurotoxin DC in complex with human synaptotagmin I | x-ray diffraction | D, E, F | — | — |
| 4ISQ | Binding domain of botulinum neurotoxin dc in complex with human synaptotagmin I | x-ray diffraction | D, E, F | — | — |
| 4V11 | Structure of Synaptotagmin-1 with SV2A peptide phosphorylated at Thr84 | x-ray diffraction | A | — | — |
| 4V11 | Structure of synaptotagmin-1 with SV2A peptide phosphorylated at THR84 | x-ray diffraction | A | — | — |
| 6G5F | Crystal structure of an engineered botulinum neurotoxin type B mutant E1191M/S1199Y in complex with… | x-ray diffraction | P | — | — |
| 6G5K | Crystal structure of the binding domain of botulinum neurotoxin type B in complex with human… | x-ray diffraction | C, D | — | — |
| 6QNS | Crystal structure of the binding domain of botulinum neurotoxin type B mutant I1248W/V1249W in… | x-ray diffraction | S | — | — |
| 6TZ3 | Crystal structure of human synaptotagmin 1 C2B without CA2+ | x-ray diffraction | A | SO4 | — |
| 6U41 | 1.7 ångström structure of a pathogenic human syt 1 C2B (D304G) | x-ray diffraction | A | SO4 | — |
| 6U4U | 1.3 a structure of a pathogenic human syt 1 C2B (I368T) | x-ray diffraction | A | SO4 | — |
| 6U4W | 1.4 a structure of a pathogenic human syt 1 C2B (D366E) | x-ray diffraction | A | SO4 | — |
| P21579 | AlphaFold monomer V2.0 prediction for synaptotagmin-1 (P21579) | predicted | A | — | 2 (best 0.40) |
Ligands
- SO4 · Sulfate ion · in 4 records
Experiment against prediction
- 6TZ3 chain A against the predicted model P21579: TM-score 0.99, RMSD 0.64 Å
- 6U4U chain A against the predicted model P21579: TM-score 0.98, RMSD 0.77 Å
- 6U4W chain A against the predicted model P21579: TM-score 0.98, RMSD 0.83 Å
- 4V11 chain A against the predicted model P21579: TM-score 0.97, RMSD 1.04 Å
- 4V11 chain A against the predicted model P21579: TM-score 0.97, RMSD 1.04 Å
- 6U41 chain A against the predicted model P21579: TM-score 0.97, RMSD 0.89 Å
- 3F05 chain A against the predicted model P21579: TM-score 0.94, RMSD 1.13 Å
- 3F05 chain A against the predicted model P21579: TM-score 0.94, RMSD 1.13 Å
- 3F04 chain A against the predicted model P21579: TM-score 0.92, RMSD 1.47 Å
- 3F04 chain A against the predicted model P21579: TM-score 0.92, RMSD 1.47 Å
Elsewhere
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