MolNFT v1 · #432107 · protein
AlphaFold monomer V2.0 prediction for solute carrier organic anion transporter family member 1B1 (Q9Y6L6)
Q9Y6L6: “AlphaFold monomer V2.0 prediction for solute carrier organic anion transporter family member 1B1 (Q9Y6L6)”. 8 pockets (best druggability 0.79). MolNFT v1 #432107 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- Q9Y6L6
- Type
- protein
- Length
- 691 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x7ad62b15d01a841965B3e7E27eef5210ceE38F38
- Molecule
- Solute carrier organic anion transporter family member 1B1
- UniProt
- Q9Y6L6
- Pockets
- 8 · best druggability 0.79
Structure
1 distinct chain · 62% helix, 5% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Solute carrier organic anion transporter family member 1B1 | protein | 691 | 62% helix, 5% strand | Q9Y6L6 |
Pockets
8 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1018 | 0.79 | 0.80 | 61 | empty |
| 2 | 674 | 0.71 | 0.79 | 71 | empty |
| 3 | 52 | 0.63 | 0.94 | 25 | empty |
| 4 | 91 | 0.37 | 0.75 | 14 | empty |
| 5 | 52 | 0.33 | 0.77 | 14 | empty |
Modifications
Observed in the structure: 8 disulfide (disulfide).
Compared structures
- 8HND · Cryo-EM structure of human OATP1B1 in complex with estrone-3-sulfate · an experimental structure of the same protein · chain A against A, TM-score 0.79
- 8HNC · Cryo-EM structure of human OATP1B1 in complex with bilirubin · an experimental structure of the same protein · chain A against A, TM-score 0.67
- 8HNB · Cryo-EM structure of human OATP1B1 in apo state · an experimental structure of the same protein · chain A against A, TM-score 0.67
- 8HNH · Cryo-EM structure of human OATP1B1 in complex with simeprevir · an experimental structure of the same protein · chain A against A, TM-score 0.66
- 8K6L · Cryo-EM structure of human OATP1B1 in complex with DCF · an experimental structure of the same protein · chain A against A, TM-score 0.65
- 8PHW · Human OATP1B1 · an experimental structure of the same protein · chain A against A, TM-score 0.64
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9Y6L6
- Elsewhere: UniProt Q9Y6L6 · AlphaFold DB Q9Y6L6
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