Research workbench
AlphaFold monomer V2.0 prediction for solute carrier organic anion transporter family member 1B1 (Q9Y6L6)
Analyse AlphaFold monomer V2.0 prediction for solute carrier organic anion transporter… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- Accession
- Q9Y6L6
- Type
- protein
- Length
- 691 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x7ad62b15d01a841965B3e7E27eef5210ceE38F38
- Molecule
- Solute carrier organic anion transporter family member 1B1
- UniProt
- Q9Y6L6
- Pockets
- 8 · best druggability 0.79
Structure
1 distinct chain · 62% helix, 5% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Solute carrier organic anion transporter family member 1B1 | protein | 691 | 62% helix, 5% strand | Q9Y6L6 |
Pockets
8 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1018 | 0.79 | 0.80 | 61 | empty |
| 2 | 674 | 0.71 | 0.79 | 71 | empty |
| 3 | 52 | 0.63 | 0.94 | 25 | empty |
| 4 | 91 | 0.37 | 0.75 | 14 | empty |
| 5 | 52 | 0.33 | 0.77 | 14 | empty |
Modifications
Observed in the structure: 8 disulfide (disulfide).
Compared structures
- 8HND · Cryo-EM structure of human OATP1B1 in complex with estrone-3-sulfate · an experimental structure of the same protein · chain A against A, TM-score 0.79
- 8HNC · Cryo-EM structure of human OATP1B1 in complex with bilirubin · an experimental structure of the same protein · chain A against A, TM-score 0.67
- 8HNB · Cryo-EM structure of human OATP1B1 in apo state · an experimental structure of the same protein · chain A against A, TM-score 0.67
- 8HNH · Cryo-EM structure of human OATP1B1 in complex with simeprevir · an experimental structure of the same protein · chain A against A, TM-score 0.66
- 8K6L · Cryo-EM structure of human OATP1B1 in complex with DCF · an experimental structure of the same protein · chain A against A, TM-score 0.65
- 8PHW · Human OATP1B1 · an experimental structure of the same protein · chain A against A, TM-score 0.64
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9Y6L6
- Elsewhere: UniProt Q9Y6L6 · AlphaFold DB Q9Y6L6
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