UniProt Q9Y6L6
Solute carrier organic anion transporter family member 1B1 (Q9Y6L6)
Solute carrier organic anion transporter family member 1B1 (UniProt Q9Y6L6): 6 experimental structures and 1 predicted model on GenesisL1, 6 ligands bound, 37 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- Q9Y6L6
- Protein
- Solute carrier organic anion transporter family member 1B1
- Experimental structures
- 6
- Predicted models
- 1
- Ligands
- 6
- Pockets
- 37 · 7 records with a druggable one
Structures
7 records of Q9Y6L6 in the MolNFT archive: 6 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 8HNB | Cryo-EM structure of human OATP1B1 in apo state | electron microscopy | A | NAG | 5 (best 0.82) |
| 8HNC | Cryo-EM structure of human OATP1B1 in complex with bilirubin | electron microscopy | A | NAG, BLR | 2 (best 0.80) |
| 8HND | Cryo-EM structure of human OATP1B1 in complex with estrone-3-sulfate | electron microscopy | A | NAG, FY5 | 5 (best 0.83) |
| 8HNH | Cryo-EM structure of human OATP1B1 in complex with simeprevir | electron microscopy | A | NAG, 30B | 5 (best 0.82) |
| 8K6L | Cryo-EM structure of human OATP1B1 in complex with DCF | electron microscopy | A | NAG, IOQ | 5 (best 0.80) |
| 8PHW | Human OATP1B1 | electron microscopy | A | FY5, Y01 | 7 (best 0.82) |
| Q9Y6L6 | AlphaFold monomer V2.0 prediction for solute carrier organic anion transporter family member 1B1… | predicted | A | — | 8 (best 0.79) |
Ligands
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 5 records
- FY5 · estrone 3-sulfate · in 2 records
- 30B · (2R,3aR,10Z,11aS,12aR,14aR)-N-(cyclopropylsulfonyl)-2-({7-methoxy-8-methyl-2-[4-(1-methylethyl)-1,3-thiazol-2-yl]quinolin-4-yl}oxy)-5-methyl-4,14-dioxo-2,3,3a,4,5,6,7,8,9,11a,12,13,14,14a-tetradecahydrocyclopenta[c]cyclopropa[g][1,6]diazacyclotetradecine-12a(1H)-carboxamide · in 1 record
- BLR · 3-[5-[(Z)-(4-ethenyl-3-methyl-5-oxidanylidene-pyrrol-2-ylidene)methyl]-2-[[5-[(Z)-(3-ethenyl-4-methyl-5-oxidanylidene-pyrrol-2-ylidene)methyl]-3-(3-hydroxy-3-oxopropyl)-4-methyl-1H-pyrrol-2-yl]methyl]-4-methyl-1H-pyrrol-3-yl]propanoic acid · in 1 record
- IOQ · 2',7'-bis(chloranyl)-3',6'-bis(oxidanyl)spiro[2-benzofuran-3,9'-xanthene]-1-one · in 1 record
- Y01 · Cholesterol hemisuccinate · in 1 record
Experiment against prediction
- 8PHW chain A against the predicted model Q9Y6L6: TM-score 0.97, RMSD 1.31 Å
- 8HND chain A against the predicted model Q9Y6L6: TM-score 0.97, RMSD 1.65 Å
- 8HNB chain A against the predicted model Q9Y6L6: TM-score 0.81, RMSD 4.58 Å
- 8K6L chain A against the predicted model Q9Y6L6: TM-score 0.80, RMSD 4.58 Å
- 8HNH chain A against the predicted model Q9Y6L6: TM-score 0.80, RMSD 4.61 Å
- 8HNC chain A against the predicted model Q9Y6L6: TM-score 0.80, RMSD 4.61 Å
Elsewhere
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