MolNFT v1 · #421175 · protein
AlphaFold monomer V2.0 prediction for sterol regulatory element- binding protein cleavage-activating protein (Q12770)
Q12770 · Sterol regulatory element-binding protein cleavage…: “AlphaFold monomer V2.0 prediction for sterol regulatory element- binding protein cleavage-activating protein…”. 18 pockets (best druggability 0.77). MolNFT v1 #421175 on…
- Accession
- Q12770
- Type
- protein
- Length
- 1,279 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x9F605311B7e26e76340423EfAfbE5e2EFc7A0b7C
- Molecule
- Sterol regulatory element-binding protein cleavage- activating protein
- UniProt
- Q12770
- Pockets
- 18 · best druggability 0.77
Structure
1 distinct chain · 28% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Sterol regulatory element-binding protein cleavage- activating protein | protein | 1279 | 28% helix, 20% strand | Q12770 |
Pockets
18 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1103 | 0.77 | 0.79 | 110 | empty |
| 2 | 58 | 0.70 | 0.96 | 19 | empty |
| 3 | 918 | 0.67 | 0.73 | 63 | empty |
| 4 | 158 | 0.67 | 0.87 | 32 | empty |
| 5 | 392 | 0.58 | 0.74 | 24 | empty |
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 7ETW · Cryo-EM structure of SCAP/INSIG complex in the present of digitonin. · an experimental structure of the same protein · chain A against B, TM-score 0.21
- 7ETW · Cryo-EM structure of Scap/Insig complex in the present of digitonin. · an experimental structure of the same protein · chain A against B, TM-score 0.21
- 6M49 · Cryo-EM structure of SCAP/INSIG complex in the present of 25-hydroxyl cholesterol. · an experimental structure of the same protein · chain A against B, TM-score 0.16
- 6M49 · cryo-EM structure of Scap/Insig complex in the present of 25-hydroxyl cholesterol. · an experimental structure of the same protein · chain A against B, TM-score 0.16
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q12770
- Elsewhere: UniProt Q12770 · AlphaFold DB Q12770
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