UniProt Q12770
Sterol regulatory element-binding protein cleavage- activating protein (Q12770)
Sterol regulatory element-binding protein cleavage- activating protein (UniProt Q12770): 3 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 29 pockets. Binding sites, druggability and experiment…
- UniProt
- Q12770
- Protein
- Sterol regulatory element-binding protein cleavage- activating protein
- Experimental structures
- 3
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 29 · 2 records with a druggable one
Structures
4 records of Q12770 in the MolNFT archive: 3 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6M49 | Cryo-EM structure of SCAP/INSIG complex in the present of 25-hydroxyl cholesterol. | electron microscopy | B | HC3 | — |
| 7ETW | Cryo-EM structure of Scap/Insig complex in the present of digitonin. | electron microscopy | B | NAG, AJP | 11 (best 0.80) |
| 7ETW | Cryo-EM structure of SCAP/INSIG complex in the present of digitonin. | electron microscopy | B | NAG, AJP | — |
| Q12770 | AlphaFold monomer V2.0 prediction for sterol regulatory element- binding protein… | predicted | A | — | 18 (best 0.77) |
Ligands
Experiment against prediction
- 6M49 chain B against the predicted model Q12770: TM-score 0.77, RMSD 2.90 Å
- 7ETW chain B against the predicted model Q12770: TM-score 0.52, RMSD 4.03 Å
- 7ETW chain B against the predicted model Q12770: TM-score 0.52, RMSD 4.03 Å
Elsewhere
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