MolNFT v1 · #385821 · protein
AlphaFold monomer V2.0 prediction for 26S proteasome regulatory subunit RPN6 (Q12377)
Q12377: “AlphaFold monomer V2.0 prediction for 26S proteasome regulatory subunit RPN6 (Q12377)”. 4 pockets (best druggability 0.63). MolNFT v1 #385821 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- Q12377
- Type
- protein
- Length
- 434 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0xBa07a45B8DC60898f701d03c6ae0Ec6dD18010B2
- Molecule
- 26S proteasome regulatory subunit RPN6
- UniProt
- Q12377
- Pockets
- 4 · best druggability 0.63
Structure
1 distinct chain · 77% helix, 3% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | 26S proteasome regulatory subunit RPN6 | protein | 434 | 77% helix, 3% strand | Q12377 |
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 427 | 0.63 | 0.77 | 37 | empty |
| 2 | 100 | 0.44 | 0.79 | 16 | empty |
| 3 | 69 | 0.32 | 0.76 | 9 | empty |
| 4 | 56 | 0.31 | 0.76 | 15 | empty |
Compared structures
- 5MPD · 26S proteasome in presence of ATP (S1) · an experimental structure of the same protein · chain A against Q, TM-score 0.86
- 5MPD · 26S proteasome in presence of ATP (s1) · an experimental structure of the same protein · chain A against Q, TM-score 0.86
- 6FVT · 26S proteasome, s1 state · an experimental structure of the same protein · chain A against Q, TM-score 0.86
- 6J2Q · Yeast proteasome in Ub-accepted state (C1-b) · an experimental structure of the same protein · chain A against Q, TM-score 0.85
- 3JCP · Structure of yeast 26S proteasome in M2 state derived from Titan dataset · an experimental structure of the same protein · chain A against Q, TM-score 0.85
- 6J2X · Yeast proteasome in resting state (C1-a) · an experimental structure of the same protein · chain A against Q, TM-score 0.84
- 4CR2 · Deep classification of a large cryo-EM dataset defines the conformational landscape of… · an experimental structure of the same protein · chain A against Q, TM-score 0.84
- 4CR2 · Deep classification of a large cryo-EM dataset defines the conformational landscape of… · an experimental structure of the same protein · chain A against Q, TM-score 0.84
- 5WVI · The resting state of yeast proteasome · an experimental structure of the same protein · chain A against Q, TM-score 0.84
- 6FVY · 26S proteasome, s6 state · an experimental structure of the same protein · chain A against Q, TM-score 0.83
- 6FVU · 26S proteasome, s2 state · an experimental structure of the same protein · chain A against Q, TM-score 0.83
- 5MPE · 26S proteasome in presence of ATP (s2) · an experimental structure of the same protein · chain A against Q, TM-score 0.83
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q12377
- Elsewhere: UniProt Q12377 · AlphaFold DB Q12377
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