UniProt Q12377
26S proteasome regulatory subunit RPN6 (Q12377)
26S proteasome regulatory subunit RPN6 (UniProt Q12377): 35 experimental structures and 1 predicted model on GenesisL1, 22 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q12377
- Protein
- 26S proteasome regulatory subunit RPN6
- Experimental structures
- 35
- Predicted models
- 1
- Pockets
- 22 · 11 records with a druggable one
Structures
36 records of Q12377 in the MolNFT archive: 35 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3J47 | Formation of an intricate helical bundle dictates the assembly of the 26S proteasome lid | electron microscopy | Q | — | — |
| 3J47 | Formation of an intricate helical bundle dictates the assembly of the 26S proteasome lid | electron microscopy | Q | — | — |
| 3JCK | Structure of the yeast 26S proteasome lid sub-complex | electron microscopy | C | — | — |
| 3JCK | Structure of the yeast 26S proteasome lid sub-complex | electron microscopy | C | — | — |
| 3JCO | Structure of yeast 26S proteasome in M1 state derived from Titan dataset | electron microscopy | Q | — | — |
| 3JCP | Structure of yeast 26S proteasome in M2 state derived from Titan dataset | electron microscopy | Q | — | — |
| 4CR2 | Deep classification of a large cryo-EM dataset defines the conformational landscape of the 26S… | electron microscopy | Q | — | — |
| 4CR2 | Deep classification of a large cryo-EM dataset defines the conformational landscape of the 26S… | electron microscopy | Q | — | — |
| 4CR3 | Deep classification of a large cryo-EM dataset defines the conformational landscape of the 26S… | electron microscopy | Q | — | — |
| 4CR3 | Deep classification of a large cryo-EM dataset defines the conformational landscape of the 26S… | electron microscopy | Q | — | — |
| 4CR4 | Deep classification of a large cryo-EM dataset defines the conformational landscape of the 26S… | electron microscopy | Q | — | — |
| 4CR4 | Deep classification of a large cryo-EM dataset defines the conformational landscape of the 26S… | electron microscopy | Q | — | — |
| 5A5B | Structure of the 26S proteasome-Ubp6 complex | electron microscopy | Q | — | — |
| 5A5B | Structure of the 26S proteasome-UBP6 complex | electron microscopy | Q | — | — |
| 5MPB | 26S proteasome in presence of AMP-PNP (s3) | electron microscopy | Q | — | — |
| 5MPC | 26S proteasome in presence of BeFx (s4) | electron microscopy | Q | — | — |
| 5MPD | 26S proteasome in presence of ATP (s1) | electron microscopy | Q | — | 2 (best 0.67) |
| 5MPD | 26S proteasome in presence of ATP (S1) | electron microscopy | Q | — | — |
| 5MPE | 26S proteasome in presence of ATP (s2) | electron microscopy | Q | — | — |
| 5MPE | 26S proteasome in presence of ATP (S2) | electron microscopy | Q | — | — |
| 5WVI | The resting state of yeast proteasome | electron microscopy | Q | — | — |
| 5WVK | Yeast proteasome-ADP-AlFx | electron microscopy | Q | — | 2 (best 0.82) |
| 6FVT | 26S proteasome, s1 state | electron microscopy | Q | — | — |
| 6FVU | 26S proteasome, s2 state | electron microscopy | Q | — | 1 (best 0.78) |
| 6FVV | 26S proteasome, s3 state | electron microscopy | Q | — | 1 (best 0.75) |
| 6FVW | 26S proteasome, s4 state | electron microscopy | Q | — | 1 (best 0.75) |
| 6FVX | 26S proteasome, s5 state | electron microscopy | Q | — | 3 (best 0.78) |
| 6FVY | 26S proteasome, s6 state | electron microscopy | Q | — | — |
| 6J2C | Yeast proteasome in translocation competent state (C3-a) | electron microscopy | Q | — | 1 (best 0.82) |
| 6J2N | yeast proteasome in substrate-processing state (C3-b) | electron microscopy | Q | — | — |
| 6J2X | Yeast proteasome in resting state (C1-a) | electron microscopy | Q | — | — |
| 6J30 | yeast proteasome in Ub-engaged state (C2) | electron microscopy | Q | — | 2 (best 0.82) |
| 7QO3 | Structure of the 26S proteasome-Ubp6 complex in the si state (Core Particle and Lid) | electron microscopy | Q | — | 3 (best 0.77) |
| 7QO3 | Structure of the 26S proteasome-UBP6 complex in the si state (core particle and lid) | electron microscopy | Q | — | — |
| 7QO5 | 26S proteasome Rpt1-RK -Ubp6-UbVS complex in the si state | electron microscopy | Q | — | 2 (best 0.82) |
| Q12377 | AlphaFold monomer V2.0 prediction for 26S proteasome regulatory subunit RPN6 (Q12377) | predicted | A | — | 4 (best 0.63) |
Experiment against prediction
- 3J47 chain Q against the predicted model Q12377: TM-score 0.87, RMSD 0.34 Å
- 3J47 chain Q against the predicted model Q12377: TM-score 0.87, RMSD 0.34 Å
- 5MPD chain Q against the predicted model Q12377: TM-score 0.86, RMSD 3.42 Å
- 5MPD chain Q against the predicted model Q12377: TM-score 0.86, RMSD 3.42 Å
- 6FVT chain Q against the predicted model Q12377: TM-score 0.86, RMSD 3.25 Å
- 3JCP chain Q against the predicted model Q12377: TM-score 0.85, RMSD 3.34 Å
- 6J2X chain Q against the predicted model Q12377: TM-score 0.85, RMSD 3.34 Å
- 4CR2 chain Q against the predicted model Q12377: TM-score 0.85, RMSD 3.37 Å
- 4CR2 chain Q against the predicted model Q12377: TM-score 0.85, RMSD 3.37 Å
- 5WVI chain Q against the predicted model Q12377: TM-score 0.85, RMSD 3.48 Å
Elsewhere
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