MolNFT v1 · #384978 · protein
AlphaFold monomer V2.0 prediction for DNA-directed RNA polymerase II subunit RPB1 (P11414)
P11414: “AlphaFold monomer V2.0 prediction for DNA-directed RNA polymerase II subunit RPB1 (P11414)”. 20 pockets (best druggability 0.80). MolNFT v1 #384978 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- P11414
- Type
- protein
- Length
- 1,970 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x97EfFf2d74994e28D3b69b1503Bd9c292B2Df480
- Molecule
- DNA-directed RNA polymerase II subunit RPB1
- UniProt
- P11414
- Pockets
- 20 · best druggability 0.80
Structure
1 distinct chain · 32% helix, 12% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | DNA-directed RNA polymerase II subunit RPB1 | protein | 1970 | 32% helix, 12% strand | P11414 |
Pockets
20 pockets found on a 1 Å grid, 11 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 978 | 0.80 | 0.81 | 88 | empty |
| 2 | 761 | 0.74 | 0.79 | 78 | empty |
| 3 | 683 | 0.72 | 0.78 | 46 | empty |
| 4 | 328 | 0.66 | 0.81 | 30 | empty |
| 5 | 358 | 0.63 | 0.79 | 46 | empty |
Compared structures
- 7B0Y · Structure of a transcribing RNA polymerase II-U1 snrnp complex · an experimental structure of the same protein · chain A against A, TM-score 0.71
- 7OPD · Pol II-csb-CRL4CSA-uvssa-SPT6-paf (structure 5) · an experimental structure of the same protein · chain A against A, TM-score 0.70
- 7OPC · Pol II-csb-CRL4CSA-uvssa-SPT6-paf (structure 4) · an experimental structure of the same protein · chain A against A, TM-score 0.70
- 7OO3 · Pol II-csb-csa-DDB1-uvssa (STRUCTURE1) · an experimental structure of the same protein · chain A against A, TM-score 0.70
- 7OOP · Pol II-csb-csa-DDB1-uvssa-paf-SPT6 (structure 3) · an experimental structure of the same protein · chain A against A, TM-score 0.70
- 7OOB · Pol II-csb-csa-DDB1-uvssa-ADPBEF3 (STRUCTURE2) · an experimental structure of the same protein · chain A against A, TM-score 0.70
- 7OOB · Pol II-CSB-CSA-DDB1-UVSSA-ADPBeF3 (Structure2) · an experimental structure of the same protein · chain A against A, TM-score 0.70
- 7OKX · Structure of active transcription elongation complex pol II-dsif (SPT5-KOW5)-ELL2-EAF1… · an experimental structure of the same protein · chain A against A, TM-score 0.70
- 7OKX · Structure of active transcription elongation complex Pol II-DSIF (SPT5-KOW5)-ELL2-EAF1… · an experimental structure of the same protein · chain A against A, TM-score 0.70
- 7OKY · Structure of active transcription elongation complex pol II-dsif-ELL2- EAF1(COMPOSITE… · an experimental structure of the same protein · chain A against A, TM-score 0.70
- 8P4E · Structural insights into human co-transcriptional capping - structure 5 · an experimental structure of the same protein · chain A against A, TM-score 0.70
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P11414
- Elsewhere: UniProt P11414 · AlphaFold DB P11414
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