UniProt P11414
DNA-directed RNA polymerase II subunit RPB1 (P11414)
DNA-directed RNA polymerase II subunit RPB1 (UniProt P11414), EC 2.7.7.6: 19 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 171 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P11414
- Protein
- DNA-directed RNA polymerase II subunit RPB1
- EC
- 2.7.7.6
- Experimental structures
- 19
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 171 · 12 records with a druggable one
Structures
20 records of P11414 in the MolNFT archive: 19 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7B0Y | Structure of a transcribing RNA polymerase II-U1 snrnp complex | electron microscopy | A | ZN, MG | — |
| 7OKX | Structure of active transcription elongation complex Pol II-DSIF (SPT5-KOW5)-ELL2-EAF1 (composite… | electron microscopy | A | MG, ZN | 15 (best 0.88) |
| 7OKX | Structure of active transcription elongation complex pol II-dsif (SPT5-KOW5)-ELL2-EAF1 (composite… | electron microscopy | A | MG, ZN | — |
| 7OKY | Structure of active transcription elongation complex Pol II-DSIF-ELL2-EAF1(composite structure) | electron microscopy | A | MG, ZN | 16 (best 0.88) |
| 7OKY | Structure of active transcription elongation complex pol II-dsif-ELL2- EAF1(COMPOSITE structure) | electron microscopy | A | MG, ZN | — |
| 7OO3 | Pol II-CSB-CSA-DDB1-UVSSA (Structure1) | electron microscopy | A | ZN, MG | 9 (best 0.88) |
| 7OO3 | Pol II-csb-csa-DDB1-uvssa (STRUCTURE1) | electron microscopy | A | ZN, MG | — |
| 7OOB | Pol II-CSB-CSA-DDB1-UVSSA-ADPBeF3 (Structure2) | electron microscopy | A | ZN, MG | 12 (best 0.87) |
| 7OOB | Pol II-csb-csa-DDB1-uvssa-ADPBEF3 (STRUCTURE2) | electron microscopy | A | ZN, MG | — |
| 7OOP | Pol II-CSB-CSA-DDB1-UVSSA-PAF-SPT6 (Structure 3) | electron microscopy | A | ZN, MG | 8 (best 0.88) |
| 7OOP | Pol II-csb-csa-DDB1-uvssa-paf-SPT6 (structure 3) | electron microscopy | A | ZN, MG | — |
| 7OPC | Pol II-csb-CRL4CSA-uvssa-SPT6-paf (structure 4) | electron microscopy | A | ZN, MG | — |
| 7OPD | Pol II-csb-CRL4CSA-uvssa-SPT6-paf (structure 5) | electron microscopy | A | ZN, MG | — |
| 8OEU | Structure of the mammalian Pol II-SPT6 complex (composite structure, Structure 4) | electron microscopy | A | MG, ZN | 16 (best 0.89) |
| 8OF0 | Structure of the mammalian Pol II-SPT6-Elongin complex, Structure 1 | electron microscopy | A | MG, ZN | 13 (best 0.88) |
| 8P4C | Structural insights into human co-transcriptional capping - structure 3 | electron microscopy | A | ZN, MG | 16 (best 0.85) |
| 8P4D | Structural insights into human co-transcriptional capping - structure 4 | electron microscopy | A | — | 16 (best 0.85) |
| 8P4E | Structural insights into human co-transcriptional capping - structure 5 | electron microscopy | A | MG, ZN | 14 (best 0.85) |
| 8P4F | Structural insights into human co-transcriptional capping - structure 6 | electron microscopy | A | ZN, MG | 16 (best 0.89) |
| P11414 | AlphaFold monomer V2.0 prediction for DNA-directed RNA polymerase II subunit RPB1 (P11414) | predicted | A | — | 20 (best 0.80) |
Ligands
Experiment against prediction
- 8P4F chain A against the predicted model P11414: TM-score 0.98, RMSD 1.67 Å
- 7OKX chain A against the predicted model P11414: TM-score 0.98, RMSD 1.74 Å
- 7OKX chain A against the predicted model P11414: TM-score 0.98, RMSD 1.74 Å
- 7OKY chain A against the predicted model P11414: TM-score 0.98, RMSD 1.74 Å
- 7OKY chain A against the predicted model P11414: TM-score 0.98, RMSD 1.74 Å
- 8OF0 chain A against the predicted model P11414: TM-score 0.98, RMSD 1.74 Å
- 8OEU chain A against the predicted model P11414: TM-score 0.98, RMSD 1.75 Å
- 8P4E chain A against the predicted model P11414: TM-score 0.98, RMSD 1.89 Å
- 7OPD chain A against the predicted model P11414: TM-score 0.98, RMSD 1.88 Å
- 7OPC chain A against the predicted model P11414: TM-score 0.98, RMSD 1.88 Å
Elsewhere
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