MolNFT v1 · #384942 · protein

AlphaFold monomer V2.0 prediction for putative RNA polymerase II subunit B1 ctd phosphatase RPAP2 (Q8IXW5)

Q8IXW5: “AlphaFold monomer V2.0 prediction for putative RNA polymerase II subunit B1 ctd phosphatase RPAP2 (Q8IXW5)”. 4 pockets (best druggability 0.56). MolNFT v1 #384942 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

Accession: Q8IXW5
Type: protein
Length: 612 residues
Chains: 1
Collection: MolNFT v1 / AlphaFold
Contract: 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
Owner: 0x40B9C9d5F084D34d026E9d5Dd10501AcdF6d6152
Molecule: Putative RNA polymerase II subunit B1 ctd phosphatase RPAP2
UniProt: Q8IXW5
Pockets: 4 · best druggability 0.56

Structure

1 distinct chain · 39% helix, 2% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Putative RNA polymerase II subunit B1 ctd phosphatase RPAP2	protein	612	39% helix, 2% strand	Q8IXW5

Pockets

4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	237	0.56	0.78	31	empty
2	156	0.51	0.79	22	empty
3	156	0.44	0.75	18	empty
4	55	0.32	0.76	13	empty

Compared structures

7B7U · Cryo-EM structure of mammalian RNA polymerase II in complex with human RPAP2 · an experimental structure of the same protein · chain A against M, TM-score 0.17

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8IXW5
Elsewhere: UniProt Q8IXW5 · AlphaFold DB Q8IXW5

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