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AlphaFold monomer V2.0 prediction for putative RNA polymerase II subunit B1 ctd phosphatase RPAP2 (Q8IXW5)

Analyse AlphaFold monomer V2.0 prediction for putative RNA polymerase II subunit B1 ctd… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

Accession: Q8IXW5
Type: protein
Length: 612 residues
Chains: 1
Collection: MolNFT v1 / AlphaFold
Contract: 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
Owner: 0x40B9C9d5F084D34d026E9d5Dd10501AcdF6d6152
Molecule: Putative RNA polymerase II subunit B1 ctd phosphatase RPAP2
UniProt: Q8IXW5
Pockets: 4 · best druggability 0.56

Structure

1 distinct chain · 39% helix, 2% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Putative RNA polymerase II subunit B1 ctd phosphatase RPAP2	protein	612	39% helix, 2% strand	Q8IXW5

Pockets

4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	237	0.56	0.78	31	empty
2	156	0.51	0.79	22	empty
3	156	0.44	0.75	18	empty
4	55	0.32	0.76	13	empty

Compared structures

7B7U · Cryo-EM structure of mammalian RNA polymerase II in complex with human RPAP2 · an experimental structure of the same protein · chain A against M, TM-score 0.17

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8IXW5
Elsewhere: UniProt Q8IXW5 · AlphaFold DB Q8IXW5

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