MolNFT v1 · #321140 · protein
AlphaFold monomer V2.0 prediction for multifunctional protein ADE2 (P22234)
P22234: “AlphaFold monomer V2.0 prediction for multifunctional protein ADE2 (P22234)”. 3 pockets (best druggability 0.76). MolNFT v1 #321140 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- P22234
- Type
- protein
- Length
- 425 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0xb4D2d9c96b0D792d0b77e7147D724cc1F801ae58
- Molecule
- Multifunctional protein ADE2
- UniProt
- P22234
- Pockets
- 3 · best druggability 0.76
Structure
1 distinct chain · 40% helix, 25% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Multifunctional protein ADE2 | protein | 425 | 40% helix, 25% strand | P22234 |
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 594 | 0.76 | 0.82 | 60 | empty |
| 2 | 112 | 0.54 | 0.83 | 24 | empty |
| 3 | 52 | 0.32 | 0.78 | 23 | empty |
Compared structures
- 7ALE · Crystal structure of human paics in complex with inhibitor 69 · an experimental structure of the same protein · chain A against A, TM-score 0.98
- 6YB8 · Human octameric paics in complex with cair and saicar · an experimental structure of the same protein · chain A against A, TM-score 0.98
- 6YB9 · Human octameric paics in complex with saicar, AMP-pnp, and magnesium · an experimental structure of the same protein · chain A against A, TM-score 0.98
- 2H31 · Crystal structure of human PAICS, a bifunctional carboxylase and synthetase in purine… · an experimental structure of the same protein · chain A against A, TM-score 0.88
- 2H31 · Crystal structure of human paics, a bifunctional carboxylase and synthetase in purine… · an experimental structure of the same protein · chain A against A, TM-score 0.88
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P22234
- Elsewhere: UniProt P22234 · AlphaFold DB P22234
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