MolNFT v1 · #38591 · protein
Crystal structure of human paics, a bifunctional carboxylase and synthetase in purine biosynthesis
2H31 · Multifunctional protein ADE2: “Crystal structure of human paics, a bifunctional carboxylase and synthetase in purine biosynthesis”. X-ray diffraction, 1 ligand (CO2), 3 pockets (best druggability 0.50). MolNFT v1 #38591 on…
- PDB
- 2H31
- Type
- protein
- Length
- 386 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Multifunctional protein ADE2
- EC
- 6.3.2.6, 4.1.1.21
- UniProt
- P22234
- Ligands
- CO2
- Pockets
- 3 · best druggability 0.50
Structure
x-ray diffraction · 1 distinct chain · 38% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Multifunctional protein ADE2 (EC 6.3.2.6, 4.1.1.21) | protein | 386 | 38% helix, 19% strand | P22234 |
Ligands and binding sites
- CO2 · Carbon dioxide · ion · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 67 | 0.50 | 0.85 | 20 | empty |
| 2 | 102 | 0.36 | 0.74 | 19 | empty |
| 3 | 63 | 0.30 | 0.75 | 17 | empty |
Modifications
Observed in the structure: 6 modified (engineered).
Compared structures
- 2H31 · Crystal structure of human PAICS, a bifunctional carboxylase and synthetase in purine… · the same entry in another collection · chain A against A, TM-score 1.00
- P22234 · AlphaFold monomer V2.0 prediction for multifunctional protein ADE2 (P22234) · a predicted model of the same protein · chain A against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P22234
- Elsewhere: RCSB PDB 2H31 · PDBe 2H31 · UniProt P22234
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.