MolNFT v1 · #319621 · protein
AlphaFold monomer V2.0 prediction for tyrosine-protein phosphatase non-receptor type 12 (Q05209)
Q05209: “AlphaFold monomer V2.0 prediction for tyrosine-protein phosphatase non-receptor type 12 (Q05209)”. 4 pockets (best druggability 0.55). MolNFT v1 #319621 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- Q05209
- Type
- protein
- Length
- 780 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x81Cb9D6826c494c4199378382c6Eb30Ba05CC2C7
- Molecule
- Tyrosine-protein phosphatase non-receptor type 12
- UniProt
- Q05209
- Pockets
- 4 · best druggability 0.55
Structure
1 distinct chain · 17% helix, 8% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Tyrosine-protein phosphatase non-receptor type 12 | protein | 780 | 17% helix, 8% strand | Q05209 |
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 304 | 0.55 | 0.75 | 37 | empty |
| 2 | 123 | 0.52 | 0.80 | 18 | empty |
| 3 | 114 | 0.40 | 0.76 | 19 | empty |
| 4 | 58 | 0.37 | 0.79 | 14 | empty |
Compared structures
- 5HDE · Crystal Structure of PTPN12 Catalytic Domain · an experimental structure of the same protein · chain A against A, TM-score 0.38
- 5HDE · Crystal structure of PTPN12 catalytic domain · an experimental structure of the same protein · chain A against A, TM-score 0.38
- 5J8R · Crystal structure of the catalytic domain of human protein tyrosine phosphatase… · an experimental structure of the same protein · chain A against A, TM-score 0.38
- 5J8R · Crystal Structure of the Catalytic Domain of Human Protein Tyrosine Phosphatase… · an experimental structure of the same protein · chain A against A, TM-score 0.38
- 5O2P · P130CAS SH3 domain ptp-pest peptide chimera · an experimental structure of the same protein · chain A against A, TM-score 0.06
- 5O2P · p130Cas SH3 domain PTP-PEST peptide chimera · an experimental structure of the same protein · chain A against A, TM-score 0.06
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q05209
- Elsewhere: UniProt Q05209 · AlphaFold DB Q05209
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