UniProt Q05209
Tyrosine-protein phosphatase non-receptor type 12 (Q05209)
Tyrosine-protein phosphatase non-receptor type 12 (UniProt Q05209), EC 3.1.3.48: 6 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 7 pockets. Binding sites, druggability and experiment against…
- UniProt
- Q05209
- Protein
- Tyrosine-protein phosphatase non-receptor type 12
- EC
- 3.1.3.48
- Experimental structures
- 6
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 7 · 1 record with a druggable one
Structures
7 records of Q05209 in the MolNFT archive: 6 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5HDE | Crystal Structure of PTPN12 Catalytic Domain | x-ray diffraction | A | PO4 | 3 (best 0.35) |
| 5HDE | Crystal structure of PTPN12 catalytic domain | x-ray diffraction | A | — | — |
| 5J8R | Crystal Structure of the Catalytic Domain of Human Protein Tyrosine Phosphatase non-receptor Type… | x-ray diffraction | A, B, C, D | — | — |
| 5J8R | Crystal structure of the catalytic domain of human protein tyrosine phosphatase non-receptor type… | x-ray diffraction | A, B, C, D | — | — |
| 5O2P | p130Cas SH3 domain PTP-PEST peptide chimera | solution nmr | A | — | — |
| 5O2P | P130CAS SH3 domain ptp-pest peptide chimera | solution nmr | A | — | — |
| Q05209 | AlphaFold monomer V2.0 prediction for tyrosine-protein phosphatase non-receptor type 12 (Q05209) | predicted | A | — | 4 (best 0.55) |
Ligands
- PO4 · Phosphate ion · in 1 record
Experiment against prediction
- 5HDE chain A against the predicted model Q05209: TM-score 1.00, RMSD 0.41 Å
- 5HDE chain A against the predicted model Q05209: TM-score 1.00, RMSD 0.41 Å
- 5J8R chain C against the predicted model Q05209: TM-score 0.99, RMSD 0.69 Å
- 5J8R chain C against the predicted model Q05209: TM-score 0.99, RMSD 0.69 Å
- 5J8R chain D against the predicted model Q05209: TM-score 0.99, RMSD 0.71 Å
- 5J8R chain D against the predicted model Q05209: TM-score 0.99, RMSD 0.71 Å
- 5J8R chain B against the predicted model Q05209: TM-score 0.99, RMSD 0.81 Å
- 5J8R chain B against the predicted model Q05209: TM-score 0.99, RMSD 0.81 Å
- 5J8R chain A against the predicted model Q05209: TM-score 0.98, RMSD 1.06 Å
- 5J8R chain A against the predicted model Q05209: TM-score 0.98, RMSD 1.06 Å
Elsewhere
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