MolNFT v1 · #306425 · protein
AlphaFold monomer V2.0 prediction for alkaline phosphatase, tissue- nonspecific isozyme (P05186)
P05186 · Alkaline phosphatase, tissue-nonspecific isozyme: “AlphaFold monomer V2.0 prediction for alkaline phosphatase, tissue- nonspecific isozyme (P05186)”. 2 pockets (best druggability 0.31). MolNFT v1 #306425 on GenesisL1: 3D…
- Accession
- P05186
- Type
- protein
- Length
- 524 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x8719F119347D3c1a2ffc2ea3A2408f52f4c89F2A
- Molecule
- Alkaline phosphatase, tissue-nonspecific isozyme
- UniProt
- P05186
- Pockets
- 2 · best druggability 0.31
Structure
1 distinct chain · 31% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Alkaline phosphatase, tissue-nonspecific isozyme | protein | 524 | 31% helix, 17% strand | P05186 |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 60 | 0.31 | 0.75 | 19 | empty |
| 2 | 57 | 0.24 | 0.72 | 19 | empty |
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
- 7YIV · The Crystal Structure of Human Tissue Nonspecific Alkaline Phosphatase (ALPL) at Basic pH · an experimental structure of the same protein · chain A against B, TM-score 0.92
- 7YIW · The Crystal Structure of Human Tissue Nonspecific Alkaline Phosphatase (ALPL) at Acidic pH · an experimental structure of the same protein · chain A against H, TM-score 0.92
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P05186
- Elsewhere: UniProt P05186 · AlphaFold DB P05186
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