Research workbench

AlphaFold monomer V2.0 prediction for alkaline phosphatase, tissue- nonspecific isozyme (P05186)

Analyse AlphaFold monomer V2.0 prediction for alkaline phosphatase, tissue- nonspecific… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

Accession: P05186
Type: protein
Length: 524 residues
Chains: 1
Collection: MolNFT v1 / AlphaFold
Contract: 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
Owner: 0x8719F119347D3c1a2ffc2ea3A2408f52f4c89F2A
Molecule: Alkaline phosphatase, tissue-nonspecific isozyme
UniProt: P05186
Pockets: 2 · best druggability 0.31

Structure

1 distinct chain · 31% helix, 17% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Alkaline phosphatase, tissue-nonspecific isozyme	protein	524	31% helix, 17% strand	P05186

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	60	0.31	0.75	19	empty
2	57	0.24	0.72	19	empty

Modifications

Observed in the structure: 2 disulfide (disulfide).

Compared structures

7YIV · The Crystal Structure of Human Tissue Nonspecific Alkaline Phosphatase (ALPL) at Basic pH · an experimental structure of the same protein · chain A against B, TM-score 0.92
7YIW · The Crystal Structure of Human Tissue Nonspecific Alkaline Phosphatase (ALPL) at Acidic pH · an experimental structure of the same protein · chain A against H, TM-score 0.92

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P05186
Elsewhere: UniProt P05186 · AlphaFold DB P05186

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.