UniProt P05186
Alkaline phosphatase, tissue-nonspecific isozyme (P05186)
Alkaline phosphatase, tissue-nonspecific isozyme (UniProt P05186), EC 3.1.3.1, 3.9.1.1: 3 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 58 pockets. Binding sites, druggability and experiment against…
- UniProt
- P05186
- Protein
- Alkaline phosphatase, tissue-nonspecific isozyme
- EC
- 3.1.3.1, 3.9.1.1
- Experimental structures
- 3
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 58 · 3 records with a druggable one
Structures
4 records of P05186 in the MolNFT archive: 3 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7YIV | The Crystal Structure of Human Tissue Nonspecific Alkaline Phosphatase (ALPL) at Basic pH | x-ray diffraction | A, D, C, B, G, H, F, E | NAG, MG, ZN, CA | 20 (best 0.76) |
| 7YIW | The Crystal Structure of Human Tissue Nonspecific Alkaline Phosphatase (ALPL) at Acidic pH | x-ray diffraction | A, D, C, B, G, H, F, E | NAG, MG, ZN, CA | 20 (best 0.79) |
| 7YIX | The Cryo-EM Structure of Human Tissue Nonspecific Alkaline Phosphatase and Single-Chain Fragment… | electron microscopy | A, B | NAG, MG, ZN, CA | 16 (best 0.75) |
| P05186 | AlphaFold monomer V2.0 prediction for alkaline phosphatase, tissue- nonspecific isozyme (P05186) | predicted | A | — | 2 (best 0.31) |
Ligands
Experiment against prediction
- 7YIV chain D against the predicted model P05186: TM-score 1.00, RMSD 0.52 Å
- 7YIV chain B against the predicted model P05186: TM-score 1.00, RMSD 0.56 Å
- 7YIV chain C against the predicted model P05186: TM-score 1.00, RMSD 0.60 Å
- 7YIW chain H against the predicted model P05186: TM-score 1.00, RMSD 0.57 Å
- 7YIW chain F against the predicted model P05186: TM-score 1.00, RMSD 0.55 Å
- 7YIV chain F against the predicted model P05186: TM-score 1.00, RMSD 0.54 Å
- 7YIV chain A against the predicted model P05186: TM-score 0.99, RMSD 0.61 Å
- 7YIW chain G against the predicted model P05186: TM-score 0.99, RMSD 0.61 Å
- 7YIW chain B against the predicted model P05186: TM-score 0.99, RMSD 0.60 Å
- 7YIW chain A against the predicted model P05186: TM-score 0.99, RMSD 0.62 Å
Elsewhere
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