MolNFT v1 · #296194 · protein
AlphaFold monomer V2.0 prediction for prostaglandin G/H synthase 2 (P35354)
P35354: “AlphaFold monomer V2.0 prediction for prostaglandin G/H synthase 2 (P35354)”. 7 pockets (best druggability 0.78). MolNFT v1 #296194 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- P35354
- Type
- protein
- Length
- 604 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0xf083204683ca2b48e920fd04E8375004D7FA0df7
- Molecule
- Prostaglandin G/H synthase 2
- UniProt
- P35354
- Pockets
- 7 · best druggability 0.78
Structure
1 distinct chain · 49% helix, 8% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Prostaglandin G/H synthase 2 | protein | 604 | 49% helix, 8% strand | P35354 |
Pockets
7 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 140 | 0.78 | 0.95 | 31 | empty |
| 2 | 621 | 0.73 | 0.80 | 70 | empty |
| 3 | 378 | 0.67 | 0.80 | 51 | empty |
| 4 | 363 | 0.58 | 0.75 | 54 | empty |
| 5 | 150 | 0.38 | 0.72 | 25 | empty |
Modifications
Observed in the structure: 5 disulfide (disulfide).
Compared structures
- 5F1A · The Crystal Structure of Salicylate Bound to Human Cyclooxygenase-2 · an experimental structure of the same protein · chain A against A, TM-score 0.91
- 5F1A · The crystal structure of salicylate bound to human cyclooxygenase-2 · an experimental structure of the same protein · chain A against A, TM-score 0.91
- 5F19 · The crystal structure of aspirin acetylated human cyclooxygenase-2 · an experimental structure of the same protein · chain A against A, TM-score 0.91
- 5F19 · The Crystal Structure of Aspirin Acetylated Human Cyclooxygenase-2 · an experimental structure of the same protein · chain A against A, TM-score 0.91
- 5KIR · The structure of vioxx bound to human COX-2 · an experimental structure of the same protein · chain A against A, TM-score 0.91
- 5KIR · The Structure of Vioxx Bound to Human COX-2 · an experimental structure of the same protein · chain A against A, TM-score 0.91
- 5IKV · The Structure of Flufenamic Acid Bound to Human Cyclooxygenase-2 · an experimental structure of the same protein · chain A against A, TM-score 0.91
- 5IKV · The structure of flufenamic acid bound to human cyclooxygenase-2 · an experimental structure of the same protein · chain A against A, TM-score 0.91
- 5IKT · The structure of tolfenamic acid bound to human cyclooxygenase-2 · an experimental structure of the same protein · chain A against A, TM-score 0.91
- 5IKR · The structure of mefenamic acid bound to human cyclooxygenase-2 · an experimental structure of the same protein · chain A against A, TM-score 0.91
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P35354
- Elsewhere: UniProt P35354 · AlphaFold DB P35354
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