UniProt P35354
Prostaglandin G/H synthase 2 (P35354)
Prostaglandin G/H synthase 2 (UniProt P35354), EC 1.14.99.1: 14 experimental structures and 1 predicted model on GenesisL1, 12 ligands bound, 17 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- P35354
- Protein
- Prostaglandin G/H synthase 2
- EC
- 1.14.99.1
- Experimental structures
- 14
- Predicted models
- 1
- Ligands
- 12
- Pockets
- 17 · 2 records with a druggable one
Structures
15 records of P35354 in the MolNFT archive: 14 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5F19 | The Crystal Structure of Aspirin Acetylated Human Cyclooxygenase-2 | x-ray diffraction | A, B | NAG, COH, AKR | — |
| 5F19 | The crystal structure of aspirin acetylated human cyclooxygenase-2 | x-ray diffraction | A, B | — | — |
| 5F1A | The Crystal Structure of Salicylate Bound to Human Cyclooxygenase-2 | x-ray diffraction | A, B | NAG, SAL, COH, AKR | — |
| 5F1A | The crystal structure of salicylate bound to human cyclooxygenase-2 | x-ray diffraction | A, B | — | — |
| 5IKQ | The Structure of Meclofenamic Acid Bound to Human Cyclooxygenase-2 | x-ray diffraction | A, B | NAG, MAN, JMS, COH, AKR | — |
| 5IKQ | The structure of meclofenamic acid bound to human cyclooxygenase-2 | x-ray diffraction | A, B | — | — |
| 5IKR | The Structure of Mefenamic Acid Bound to Human Cyclooxygenase-2 | x-ray diffraction | A, B | NAG, ID8, COH, NH4 | — |
| 5IKR | The structure of mefenamic acid bound to human cyclooxygenase-2 | x-ray diffraction | A, B | — | — |
| 5IKT | The Structure of Tolfenamic Acid Bound to Human Cyclooxygenase-2 | x-ray diffraction | A, B | NAG, MAN, TLF, COH, PO4 | 10 (best 0.86) |
| 5IKT | The structure of tolfenamic acid bound to human cyclooxygenase-2 | x-ray diffraction | A, B | — | — |
| 5IKV | The Structure of Flufenamic Acid Bound to Human Cyclooxygenase-2 | x-ray diffraction | A, B | NAG, MAN, FLF, COH, NH4 | — |
| 5IKV | The structure of flufenamic acid bound to human cyclooxygenase-2 | x-ray diffraction | A, B | — | — |
| 5KIR | The Structure of Vioxx Bound to Human COX-2 | x-ray diffraction | A, B | NAG, RCX, COH, NH4, PO4 | — |
| 5KIR | The structure of vioxx bound to human COX-2 | x-ray diffraction | A, B | NAG, RCX, COH, NH4, PO4 | — |
| P35354 | AlphaFold monomer V2.0 prediction for prostaglandin G/H synthase 2 (P35354) | predicted | A | — | 7 (best 0.78) |
Ligands
- COH · Protoporphyrin IX containing co · in 8 records
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 8 records
- NH4 · Ammonium ion · in 4 records
- AKR · Acrylic acid · in 3 records
- MAN · alpha-D-mannopyranose · in 3 records
- PO4 · Phosphate ion · in 3 records
- RCX · Rofecoxib · in 2 records
- FLF · 2-[[3-(trifluoromethyl)phenyl]amino] benzoic acid · in 1 record
- ID8 · 2-[(2,3-dimethylphenyl)amino]benzoic acid · in 1 record
- JMS · 2-[(2,6-dichloro-3-methyl-phenyl)amino]benzoic acid · in 1 record
- SAL · 2-hydroxybenzoic acid · in 1 record
- TLF · 2-[(3-chloro-2-methylphenyl)amino]benzoic acid · in 1 record
Experiment against prediction
- 5IKT chain B against the predicted model P35354: TM-score 1.00, RMSD 0.36 Å
- 5F1A chain A against the predicted model P35354: TM-score 1.00, RMSD 0.37 Å
- 5F1A chain A against the predicted model P35354: TM-score 1.00, RMSD 0.37 Å
- 5KIR chain A against the predicted model P35354: TM-score 1.00, RMSD 0.38 Å
- 5KIR chain A against the predicted model P35354: TM-score 1.00, RMSD 0.38 Å
- 5IKV chain A against the predicted model P35354: TM-score 1.00, RMSD 0.39 Å
- 5IKV chain A against the predicted model P35354: TM-score 1.00, RMSD 0.39 Å
- 5IKT chain A against the predicted model P35354: TM-score 1.00, RMSD 0.39 Å
- 5IKT chain A against the predicted model P35354: TM-score 1.00, RMSD 0.39 Å
- 5IKR chain A against the predicted model P35354: TM-score 1.00, RMSD 0.40 Å
Elsewhere
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