AlphaFold monomer V2.0 prediction for gametocyte surface protein P45/48 (Q8I6T1)

Structure

1 distinct chain · 15% helix, 42% strand (DSSP).

Pockets

3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Modifications

Observed in the structure: 7 disulfide (disulfide).

Compared structures

• 7ZXG · PFS48/45 bound to Fab fragment of monoclonal antibody 10D8 · an experimental structure of the same protein · chain A against A, TM-score 0.71
• 7ZXF · PFS48/45 bound to monoclonal antibodies 10D8 and 85RF45.1 · an experimental structure of the same protein · chain A against A, TM-score 0.55
• 7ZWF · PFS48/45 bound to scfv fragment of monoclonal antibody 32F3 · an experimental structure of the same protein · chain A against A, TM-score 0.53
• 7ZWM · PFS48/45 central and C-terminal domains bound to Fab fragments of monoclonal antibody… · an experimental structure of the same protein · chain A against F, TM-score 0.48
• 7UNB · Crystal structure of malaria transmission-blocking antigen PFS48/45-6C variant in complex… · an experimental structure of the same protein · chain A against R, TM-score 0.30
• 7ZWI · PFS48/45 C-terminal domain bound to Fab fragment of monoclonal antibody 32F3 · an experimental structure of the same protein · chain A against A, TM-score 0.29
• 6H5N · Plasmodium falciparum PFS48/45 C-terminal domain bound to monoclonal antibody 85RF45.1 · an experimental structure of the same protein · chain A against D, TM-score 0.28

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt Q8I6T1
• Elsewhere: UniProt Q8I6T1 · AlphaFold DB Q8I6T1