UniProt Q8I6T1
Gametocyte surface protein P45/48 (Q8I6T1)
Gametocyte surface protein P45/48 (UniProt Q8I6T1): 15 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 62 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q8I6T1
- Protein
- Gametocyte surface protein P45/48
- Experimental structures
- 15
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 62 · 9 records with a druggable one
Structures
16 records of Q8I6T1 in the MolNFT archive: 15 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6H5N | Plasmodium falciparum Pfs48/45 C-terminal domain bound to monoclonal antibody 85RF45.1 | x-ray diffraction | A, D | — | 8 (best 0.61) |
| 6H5N | Plasmodium falciparum PFS48/45 C-terminal domain bound to monoclonal antibody 85RF45.1 | x-ray diffraction | A, D | — | — |
| 7UNB | Crystal structure of malaria transmission-blocking antigen Pfs48/45-6C variant in complex with… | x-ray diffraction | R | — | 3 (best 0.71) |
| 7UNB | Crystal structure of malaria transmission-blocking antigen PFS48/45-6C variant in complex with… | x-ray diffraction | R | — | — |
| 7UXL | Crystal structure of malaria transmission-blocking antigen Pfs48/45-6C variant in complex with… | x-ray diffraction | R | — | 4 (best 0.75) |
| 7ZWF | Pfs48/45 bound to scFv fragment of monoclonal antibody 32F3 | x-ray diffraction | A | NAG, FUC | 6 (best 0.60) |
| 7ZWF | PFS48/45 bound to scfv fragment of monoclonal antibody 32F3 | x-ray diffraction | A | NAG, FUC | — |
| 7ZWI | Pfs48/45 C-terminal domain bound to fab fragment of monoclonal antibody 32F3 | x-ray diffraction | A, D | NAG, FUC | 4 (best 0.58) |
| 7ZWI | PFS48/45 C-terminal domain bound to Fab fragment of monoclonal antibody 32F3 | x-ray diffraction | A, D | NAG, FUC | — |
| 7ZWM | Pfs48/45 central and C-terminal domains bound to Fab fragments of monoclonal antibody 10D8 and 32F3 | x-ray diffraction | A, F | NAG, FUC | 10 (best 0.71) |
| 7ZWM | PFS48/45 central and C-terminal domains bound to Fab fragments of monoclonal antibody 10D8 and 32F3 | x-ray diffraction | A, F | NAG, FUC | — |
| 7ZXF | Pfs48/45 bound to monoclonal antibodies 10D8 and 85RF45.1 | x-ray diffraction | A | NAG | 10 (best 0.72) |
| 7ZXF | PFS48/45 bound to monoclonal antibodies 10D8 and 85RF45.1 | x-ray diffraction | A | NAG | — |
| 7ZXG | Pfs48/45 bound to Fab fragment of monoclonal antibody 10D8 | x-ray diffraction | A, D | NAG | 14 (best 0.79) |
| 7ZXG | PFS48/45 bound to Fab fragment of monoclonal antibody 10D8 | x-ray diffraction | A, D | NAG | — |
| Q8I6T1 | AlphaFold monomer V2.0 prediction for gametocyte surface protein P45/48 (Q8I6T1) | predicted | A | — | 3 (best 0.69) |
Ligands
Experiment against prediction
- 6H5N chain D against the predicted model Q8I6T1: TM-score 0.97, RMSD 0.80 Å
- 6H5N chain D against the predicted model Q8I6T1: TM-score 0.97, RMSD 0.80 Å
- 7UXL chain R against the predicted model Q8I6T1: TM-score 0.96, RMSD 0.94 Å
- 6H5N chain A against the predicted model Q8I6T1: TM-score 0.96, RMSD 0.94 Å
- 6H5N chain A against the predicted model Q8I6T1: TM-score 0.96, RMSD 0.94 Å
- 7UNB chain R against the predicted model Q8I6T1: TM-score 0.95, RMSD 1.09 Å
- 7UNB chain R against the predicted model Q8I6T1: TM-score 0.95, RMSD 1.09 Å
- 7ZWI chain D against the predicted model Q8I6T1: TM-score 0.94, RMSD 1.34 Å
- 7ZWI chain D against the predicted model Q8I6T1: TM-score 0.94, RMSD 1.34 Å
- 7ZWI chain A against the predicted model Q8I6T1: TM-score 0.94, RMSD 1.36 Å
Elsewhere
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