MolNFT v1 · #271609 · protein
AlphaFold monomer V2.0 prediction for nt-3 growth factor receptor (Q16288)
Q16288: “AlphaFold monomer V2.0 prediction for nt-3 growth factor receptor (Q16288)”. 7 pockets (best druggability 0.76). MolNFT v1 #271609 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- Q16288
- Type
- protein
- Length
- 839 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x3d4E27cf9065B918518565E961f228A07fD3933F
- Molecule
- Nt-3 growth factor receptor
- UniProt
- Q16288
- Pockets
- 7 · best druggability 0.76
Structure
1 distinct chain · 22% helix, 25% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Nt-3 growth factor receptor | protein | 839 | 22% helix, 25% strand | Q16288 |
Pockets
7 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 506 | 0.76 | 0.83 | 62 | empty |
| 2 | 583 | 0.70 | 0.78 | 37 | empty |
| 3 | 345 | 0.69 | 0.82 | 62 | empty |
| 4 | 355 | 0.69 | 0.82 | 44 | empty |
| 5 | 466 | 0.67 | 0.79 | 43 | empty |
Modifications
Observed in the structure: 6 disulfide (disulfide).
Compared structures
- 4YMJ · (R)-2-Phenylpyrrolidine Substitute Imidazopyridazines: a New Class of Potent and… · an experimental structure of the same protein · chain A against B, TM-score 0.32
- 4YMJ · (R)-2-phenylpyrrolidine substitute imidazopyridazines: a new class of potent and… · an experimental structure of the same protein · chain A against B, TM-score 0.32
- 6KZD · Crystal structure of trkc in complex with 3-((6-(4-aminophenyl)… · an experimental structure of the same protein · chain A against A, TM-score 0.32
- 6KZD · Crystal structure of TRKc in complex with 3-((6-(4-aminophenyl)imidazo[1,2-a]pyrazin-3-yl)… · an experimental structure of the same protein · chain A against A, TM-score 0.32
- 6KZC · Crystal structure of trkc in complex with 3-(IMIDAZO[1,2-A]PYRAZIN-3… · an experimental structure of the same protein · chain A against A, TM-score 0.32
- 3V5Q · Discovery of a selective trk inhibitor with efficacy in rodent cancer tumor models · an experimental structure of the same protein · chain A against B, TM-score 0.31
- 3V5Q · Discovery of a selective TRK Inhibitor with efficacy in rodent cancer tumor models · an experimental structure of the same protein · chain A against B, TM-score 0.31
- 1WWC · NT3 binding domain of human trkc receptor · an experimental structure of the same protein · chain A against A, TM-score 0.10
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q16288
- Elsewhere: UniProt Q16288 · AlphaFold DB Q16288
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