UniProt Q16288
NT-3 growth factor receptor (Q16288)
NT-3 growth factor receptor (UniProt Q16288), EC 2.7.10.1: 10 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 10 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- Q16288
- Protein
- NT-3 growth factor receptor
- EC
- 2.7.10.1
- Experimental structures
- 10
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 10 · 2 records with a druggable one
Structures
11 records of Q16288 in the MolNFT archive: 10 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1WWC | NT3 binding domain of human trkc receptor | x-ray diffraction | A | — | — |
| 1WWC | NT3 binding domain of human trkc receptor | x-ray diffraction | A | — | — |
| 3V5Q | Discovery of a selective TRK Inhibitor with efficacy in rodent cancer tumor models | x-ray diffraction | A, B | — | — |
| 3V5Q | Discovery of a selective trk inhibitor with efficacy in rodent cancer tumor models | x-ray diffraction | A, B | — | — |
| 4YMJ | (R)-2-Phenylpyrrolidine Substitute Imidazopyridazines: a New Class of Potent and Selective Pan-TRK… | x-ray diffraction | A, B | — | — |
| 4YMJ | (R)-2-phenylpyrrolidine substitute imidazopyridazines: a new class of potent and selective pan-trk… | x-ray diffraction | A, B | — | — |
| 6KZC | crystal structure of TRKc in complex with 3-(imidazo[1,2-a]pyrazin-3-ylethynyl)-2-methyl-N-(3-((4… | x-ray diffraction | A | DZC | 3 (best 0.74) |
| 6KZC | Crystal structure of trkc in complex with 3-(IMIDAZO[1,2-A]PYRAZIN-3- ylethynyl)-2-methyl-N-(3-((4… | x-ray diffraction | A | DZC | — |
| 6KZD | Crystal structure of TRKc in complex with 3-((6-(4-aminophenyl)imidazo[1,2-a]pyrazin-3-yl)ethynyl)… | x-ray diffraction | A | DZ6, PO4 | — |
| 6KZD | Crystal structure of trkc in complex with 3-((6-(4-aminophenyl)… | x-ray diffraction | A | DZ6, PO4 | — |
| Q16288 | AlphaFold monomer V2.0 prediction for nt-3 growth factor receptor (Q16288) | predicted | A | — | 7 (best 0.76) |
Ligands
- DZ6 · 3-[2-[6-(4-aminophenyl)imidazo[1,2-a]pyrazin-3-yl]ethynyl]-2-methyl-~{N}-[3-(4-methylpiperazin-1-yl)-5-propan-2-yl-phenyl]benzamide · in 2 records
- DZC · 3-(2-imidazo[1,2-a]pyrazin-3-ylethynyl)-2-methyl-~{N}-[3-(4-methylpiperazin-1-yl)-5-(trifluoromethyl) phenyl]benzamide · in 2 records
- PO4 · Phosphate ion · in 2 records
Experiment against prediction
- 4YMJ chain A against the predicted model Q16288: TM-score 0.98, RMSD 1.03 Å
- 4YMJ chain A against the predicted model Q16288: TM-score 0.98, RMSD 1.03 Å
- 3V5Q chain B against the predicted model Q16288: TM-score 0.98, RMSD 1.11 Å
- 3V5Q chain B against the predicted model Q16288: TM-score 0.98, RMSD 1.11 Å
- 3V5Q chain A against the predicted model Q16288: TM-score 0.98, RMSD 1.13 Å
- 3V5Q chain A against the predicted model Q16288: TM-score 0.98, RMSD 1.13 Å
- 4YMJ chain B against the predicted model Q16288: TM-score 0.97, RMSD 1.41 Å
- 4YMJ chain B against the predicted model Q16288: TM-score 0.97, RMSD 1.41 Å
- 6KZC chain A against the predicted model Q16288: TM-score 0.95, RMSD 1.26 Å
- 6KZC chain A against the predicted model Q16288: TM-score 0.95, RMSD 1.26 Å
Elsewhere
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