AlphaFold monomer V2.0 prediction for oxysterols receptor lxr-beta (P55055)

Structure

1 distinct chain · 47% helix, 4% strand (DSSP).

Pockets

4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Compared structures

• 5I4V · Discovery of novel, orally efficacious Liver X Receptor (LXR) beta agonists · an experimental structure of the same protein · chain A against A, TM-score 0.52
• 5I4V · Discovery of novel, orally efficacious liver X receptor (lxr) beta agonists · an experimental structure of the same protein · chain A against A, TM-score 0.52
• 3L0E · X-ray crystal structure of a potent liver X receptor modulator · an experimental structure of the same protein · chain A against A, TM-score 0.52
• 3L0E · X-ray crystal structure of a Potent Liver X Receptor Modulator · an experimental structure of the same protein · chain A against A, TM-score 0.52
• 1PQ6 · Human lxr beta hormone receptor / GW3965 complex · an experimental structure of the same protein · chain A against B, TM-score 0.52
• 1PQ6 · Human lxr beta hormone receptor / GW3965 complex · an experimental structure of the same protein · chain A against B, TM-score 0.52
• 5KYA · Brain penetrant liver X receptor (lxr) modulators based on a 2,4,5,6… · an experimental structure of the same protein · chain A against E, TM-score 0.52
• 5HJP · Identification of lxrbeta selective agonists for the treatment of ALZHEIMER'S disease · an experimental structure of the same protein · chain A against B, TM-score 0.52
• 5KYJ · Brain penetrant liver X receptor (LXR) modulators based on a… · an experimental structure of the same protein · chain A against A, TM-score 0.52
• 5KYJ · Brain penetrant liver X receptor (lxr) modulators based on a 2,4,5,6… · an experimental structure of the same protein · chain A against A, TM-score 0.52
• 6K9G · Human lxr-beta in complex with an agonist · an experimental structure of the same protein · chain A against A, TM-score 0.52
• 1P8D · X-Ray Crystal Structure of LXR Ligand Binding Domain with 24(S),25-epoxycholesterol · an experimental structure of the same protein · chain A against B, TM-score 0.51

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P55055
• Elsewhere: UniProt P55055 · AlphaFold DB P55055