Research workbench
AlphaFold monomer V2.0 prediction for oxysterols receptor lxr-beta (P55055)
Analyse AlphaFold monomer V2.0 prediction for oxysterols receptor lxr-beta (P55055) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- Accession
- P55055
- Type
- protein
- Length
- 460 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x9a7859522C8b5BAa3f909CfabcF4eC23854808F5
- Molecule
- Oxysterols receptor lxr-beta
- UniProt
- P55055
- Pockets
- 4 · best druggability 0.85
Structure
1 distinct chain · 47% helix, 4% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Oxysterols receptor lxr-beta | protein | 460 | 47% helix, 4% strand | P55055 |
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 211 | 0.85 | 0.97 | 26 | empty |
| 2 | 175 | 0.41 | 0.73 | 22 | empty |
| 3 | 70 | 0.36 | 0.78 | 17 | empty |
| 4 | 58 | 0.31 | 0.75 | 15 | empty |
Compared structures
- 5I4V · Discovery of novel, orally efficacious Liver X Receptor (LXR) beta agonists · an experimental structure of the same protein · chain A against A, TM-score 0.52
- 5I4V · Discovery of novel, orally efficacious liver X receptor (lxr) beta agonists · an experimental structure of the same protein · chain A against A, TM-score 0.52
- 3L0E · X-ray crystal structure of a potent liver X receptor modulator · an experimental structure of the same protein · chain A against A, TM-score 0.52
- 3L0E · X-ray crystal structure of a Potent Liver X Receptor Modulator · an experimental structure of the same protein · chain A against A, TM-score 0.52
- 1PQ6 · Human lxr beta hormone receptor / GW3965 complex · an experimental structure of the same protein · chain A against B, TM-score 0.52
- 1PQ6 · Human lxr beta hormone receptor / GW3965 complex · an experimental structure of the same protein · chain A against B, TM-score 0.52
- 5KYA · Brain penetrant liver X receptor (lxr) modulators based on a 2,4,5,6… · an experimental structure of the same protein · chain A against E, TM-score 0.52
- 5KYA · Brain penetrant liver X receptor (LXR) modulators based on a… · an experimental structure of the same protein · chain A against E, TM-score 0.52
- 5HJP · Identification of lxrbeta selective agonists for the treatment of ALZHEIMER'S disease · an experimental structure of the same protein · chain A against B, TM-score 0.52
- 5HJP · Identification of LXRbeta selective agonists for the treatment of Alzheimer's Disease · an experimental structure of the same protein · chain A against B, TM-score 0.52
- 5KYJ · Brain penetrant liver X receptor (LXR) modulators based on a… · an experimental structure of the same protein · chain A against A, TM-score 0.52
- 5KYJ · Brain penetrant liver X receptor (lxr) modulators based on a 2,4,5,6… · an experimental structure of the same protein · chain A against A, TM-score 0.52
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P55055
- Elsewhere: UniProt P55055 · AlphaFold DB P55055
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