UniProt P55055

Oxysterols receptor LXR-beta (P55055)

Oxysterols receptor LXR-beta (UniProt P55055): 44 experimental structures and 1 predicted model on GenesisL1, 14 ligands bound, 59 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.

UniProt: P55055
Protein: Oxysterols receptor LXR-beta
Experimental structures: 44
Predicted models: 1
Ligands: 14
Pockets: 59 · 7 records with a druggable one

Structures

45 records of P55055 in the MolNFT archive: 44 experimental, 1 predicted.

Entry	Title	Method	Chains	Ligands	Pockets
1P8D	X-Ray Crystal Structure of LXR Ligand Binding Domain with 24(S),25-epoxycholesterol	x-ray diffraction	A, B	—	—
1P8D	X-ray crystal structure of lxr ligand binding domain with 24(S),25- epoxycholesterol	x-ray diffraction	A, B	—	—
1PQ6	Human lxr beta hormone receptor / GW3965 complex	x-ray diffraction	A, B, C, D	—	—
1PQ6	Human lxr beta hormone receptor / GW3965 complex	x-ray diffraction	A, B, C, D	—	—
1PQ9	Human lxr beta hormone receptor complexed with T0901317 complex	x-ray diffraction	A, B, C, D	—	—
1PQ9	Human lxr beta hormone receptor complexed with T0901317 complex	x-ray diffraction	A, B, C, D	—	—
1PQC	Human lxr beta hormone receptor complexed with T0901317	x-ray diffraction	A, B, C, D	—	—
1PQC	Human lxr beta hormone receptor complexed with T0901317	x-ray diffraction	A, B, C, D	—	—
1UPV	Crystal structure of the human Liver X receptor beta ligand binding domain in complex with a…	x-ray diffraction	A	—	—
1UPV	Crystal structure of the human liver X receptor beta ligand binding domain in complex with a…	x-ray diffraction	A	—	—
1UPW	Crystal structure of the human Liver X receptor beta ligand binding domain in complex with a…	x-ray diffraction	A	—	—
1UPW	Crystal structure of the human liver X receptor beta ligand binding domain in complex with a…	x-ray diffraction	A	—	—
3KFC	Complex Structure of LXR with an agonist	x-ray diffraction	A, B, C, D	—	—
3KFC	Complex structure of lxr with an agonist	x-ray diffraction	A, B, C, D	—	—
3L0E	X-ray crystal structure of a Potent Liver X Receptor Modulator	x-ray diffraction	A	—	—
3L0E	X-ray crystal structure of a potent liver X receptor modulator	x-ray diffraction	A	—	—
4DK7	Crystal structure of LXR ligand binding domain in complex with full agonist 1	x-ray diffraction	A, C	—	—
4DK7	Crystal structure of lxr ligand binding domain in complex with full agonist 1	x-ray diffraction	A, C	—	—
4DK8	Crystal structure of LXR ligand binding domain in complex with partial agonist 5	x-ray diffraction	A, C	—	—
4DK8	Crystal structure of lxr ligand binding domain in complex with partial agonist 5	x-ray diffraction	A, C	—	—
4RAK	Crystal structure of nuclear receptor subfamily 1, group h, member 2 (lxrb) complexed with partial…	x-ray diffraction	A, B	—	—
4RAK	Crystal structure of nuclear receptor subfamily 1, group H, member 2 (lxrb) complexed with partial…	x-ray diffraction	A, B	—	—
5HJP	Identification of LXRbeta selective agonists for the treatment of Alzheimer's Disease	x-ray diffraction	B, D	668	11 (best 0.86)
5HJP	Identification of lxrbeta selective agonists for the treatment of ALZHEIMER'S disease	x-ray diffraction	B, D	—	—
5I4V	Discovery of novel, orally efficacious Liver X Receptor (LXR) beta agonists	x-ray diffraction	A, E	67S	11 (best 0.85)
5I4V	Discovery of novel, orally efficacious liver X receptor (lxr) beta agonists	x-ray diffraction	A, E	—	—
5JY3	CRYSTAL STRUCTURE OF LXRbeta (NUCLEAR RECEPTOR SUBFAMILY 1, GROUP H, MEMBER 2) COMPLEXED WITH…	x-ray diffraction	A, B, C, D	6OX	15 (best 0.87)
5JY3	Crystal structure of lxrbeta (nuclear receptor subfamily 1, group H, member 2) complexed with…	x-ray diffraction	A, B, C, D	—	—
5KYA	Brain penetrant liver X receptor (lxr) modulators based on a 2,4,5,6…	x-ray diffraction	A, E	6Y4	—
5KYJ	Brain penetrant liver X receptor (LXR) modulators based on a…	x-ray diffraction	A, E	6Y8	—
5KYJ	Brain penetrant liver X receptor (lxr) modulators based on a 2,4,5,6…	x-ray diffraction	A, E	6Y8	—
6JIO	Human LXR-beta in complex with a ligand	x-ray diffraction	A, B, C, D	BQ3	—
6JIO	Human lxr-beta in complex with a ligand	x-ray diffraction	A, B, C, D	BQ3	—
6K9G	Human LXR-beta in complex with an agonist	x-ray diffraction	A, B, C, D	D3R	12 (best 0.85)
6K9G	Human lxr-beta in complex with an agonist	x-ray diffraction	A, B, C, D	D3R	—
6K9H	Human LXR-beta in complex with an agonist	x-ray diffraction	A, B	D40	—
6K9H	Human lxr-beta in complex with an agonist	x-ray diffraction	A, B	D40	—
6K9M	Human lxr-beta in complex with an agonist	x-ray diffraction	A, B, C, D	D43	—
6S4N	Lxrbeta ligand binding domain in comlpex with small molecule inhibitors	x-ray diffraction	D, A, B, C	KUW, SO4	—
6S4T	LXRbeta ligand binding domain in comlpex with small molecule inhibitors	x-ray diffraction	A	KVB	3 (best 0.84)
6S4T	Lxrbeta ligand binding domain in comlpex with small molecule inhibitors	x-ray diffraction	A	KVB	—
6S4U	Lxrbeta ligand binding domain in comlpex with small molecule inhibitors	x-ray diffraction	A, B, C	KVK	—
6S5K	LXRbeta ligand binding domain in complex with small molecule inhibitors	x-ray diffraction	A	KWE	3 (best 0.82)
6S5K	Lxrbeta ligand binding domain in complex with small molecule inhibitors	x-ray diffraction	A	KWE	—
P55055	AlphaFold monomer V2.0 prediction for oxysterols receptor lxr-beta (P55055)	predicted	A	—	4 (best 0.85)

Ligands

6Y8 · (6~{R})-5-(5-fluoranyl-2-methoxy-pyrimidin-4-yl)-2-(3-methylsulfonylphenyl)-6-propan-2-yl-4,6-dihydropyrrolo[3,4-c]pyrazole · in 2 records
BQ3 · tert-butyl 7-amino-3,4-dihydroisoquinoline-2(1H)-carboxylate · in 2 records
D3R · ~{tert}-butyl (2'~{R},3~{R})-2'-[3-[4-(hydroxymethyl)-3-methylsulfonyl-phenyl]phenyl]-2-oxidanylidene-spiro[1~{H}-indole-3,3'-pyrrolidine]-1'-carboxylate · in 2 records
D40 · ~{tert}-butyl (2'~{S},3~{S})-2-oxidanylidene-2'-phenyl-spiro[1~{H}-indole-3,3'-pyrrolidine]-1'-carboxylate · in 2 records
KVB · 2-[4-[[3-[3-(phenylmethyl)-8-(trifluoromethyl)quinolin-4-yl]phenoxy]methyl]phenyl]ethanoic acid · in 2 records
KWE · 3-(4-phenylbutylamino)-1,4-bis(phenylmethyl)pyrrole-2, 5-dione · in 2 records
668 · 2-chloro-4-{1'-[(2R)-2-hydroxy-3-methyl-2-(trifluoromethyl)butanoyl]-4,4'-bipiperidin-1-yl}-N,N-dimethylbenzamide · in 1 record
67S · {2-[(2R)-4-[4-(hydroxymethyl)-3-(methylsulfonyl)phenyl]-2-(propan-2-yl)piperazin-1-yl]-4-(trifluoromethyl)pyrimidin-5-yl}methanol · in 1 record
6OX · 2-[2-[2-[2,6-bis(chloranyl)phenyl]propan-2-yl]-1-[2-fluoranyl-4-[3-fluoranyl-4-(hydroxymethyl)-5-methylsulfonyl-phenyl] phenyl]imidazol-4-yl]propan-2-ol · in 1 record
6Y4 · [2-[(6~{R})-2-(3-methylsulfonylphenyl)-6-propan-2-yl-4, 6-dihydropyrrolo[3,4-c]pyrazol-5-yl]-4-(trifluoromethyl)pyrimidin-5-yl]methanol · in 1 record
D43 · ~{tert}-butyl (2'~{S},3~{S})-2-oxidanylidene-2'-propan-2-yl-spiro[1~{h}-indole-3,3'-pyrrolidine]-1'-carboxylate · in 1 record
KUW · 2-[5-chloranyl-6-[4-[[1,1,3-tris(oxidanylidene)-5-phenyl-2-propan-2-yl-1,2-thiazol-4-yl]amino]piperidin-1-yl]pyridin-3-yl]ethanoic acid · in 1 record
KVK · 6-[4-[[3-oxidanyl-1,1-bis(oxidanylidene)-5-phenyl-2-propan-2-yl-3~{H}-1,2-thiazol-4-yl]amino]butyl]pyridine-2-sulfonamide · in 1 record
SO4 · Sulfate ion · in 1 record

Experiment against prediction

1PQ9 chain D against the predicted model P55055: TM-score 0.99, RMSD 0.52 Å
1PQ9 chain D against the predicted model P55055: TM-score 0.99, RMSD 0.52 Å
3KFC chain C against the predicted model P55055: TM-score 0.99, RMSD 0.50 Å
3KFC chain C against the predicted model P55055: TM-score 0.99, RMSD 0.50 Å
1PQC chain D against the predicted model P55055: TM-score 0.99, RMSD 0.54 Å
1PQC chain D against the predicted model P55055: TM-score 0.99, RMSD 0.54 Å
6S4N chain D against the predicted model P55055: TM-score 0.99, RMSD 0.68 Å
1PQ6 chain C against the predicted model P55055: TM-score 0.99, RMSD 0.65 Å
1PQ6 chain C against the predicted model P55055: TM-score 0.99, RMSD 0.65 Å
6S4N chain B against the predicted model P55055: TM-score 0.98, RMSD 0.76 Å

Elsewhere

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