MolNFT v1 · #245000 · protein
AlphaFold monomer V2.0 prediction for DNA mismatch repair protein MSH2 (P43246)
P43246: “AlphaFold monomer V2.0 prediction for DNA mismatch repair protein MSH2 (P43246)”. 11 pockets (best druggability 0.75). MolNFT v1 #245000 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- P43246
- Type
- protein
- Length
- 934 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x1ED4a68B4011314730adE976b56Ad4cA21b54dcD
- Molecule
- DNA mismatch repair protein MSH2
- UniProt
- P43246
- Pockets
- 11 · best druggability 0.75
Structure
1 distinct chain · 51% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | DNA mismatch repair protein MSH2 | protein | 934 | 51% helix, 19% strand | P43246 |
Pockets
11 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 919 | 0.75 | 0.78 | 80 | empty |
| 2 | 197 | 0.70 | 0.88 | 33 | empty |
| 3 | 273 | 0.62 | 0.81 | 31 | empty |
| 4 | 556 | 0.61 | 0.74 | 53 | empty |
| 5 | 113 | 0.43 | 0.77 | 20 | empty |
Compared structures
- 2O8B · human MutSalpha (MSH2/MSH6) bound to ADP and a G T mispair · an experimental structure of the same protein · chain A against A, TM-score 0.85
- 2O8B · Human mutsalpha (MSH2/MSH6) bound to ADP and a G T mispair · an experimental structure of the same protein · chain A against A, TM-score 0.85
- 2O8C · human MutSalpha (MSH2/MSH6) bound to ADP and an O6-methyl-guanine T mispair · an experimental structure of the same protein · chain A against A, TM-score 0.85
- 2O8C · Human mutsalpha (MSH2/MSH6) bound to ADP and an O6-methyl-guanine T mispair · an experimental structure of the same protein · chain A against A, TM-score 0.85
- 2O8D · human MutSalpha (MSH2/MSH6) bound to ADP and a G dU mispair · an experimental structure of the same protein · chain A against A, TM-score 0.85
- 2O8D · Human mutsalpha (MSH2/MSH6) bound to ADP and a G du mispair · an experimental structure of the same protein · chain A against A, TM-score 0.85
- 2O8E · human MutSalpha (MSH2/MSH6) bound to a G T mispair, with ADP bound to MSH2 only · an experimental structure of the same protein · chain A against A, TM-score 0.85
- 2O8E · Human mutsalpha (MSH2/MSH6) bound to a G T mispair, with ADP bound to MSH2 only · an experimental structure of the same protein · chain A against A, TM-score 0.85
- 8R7V · MutSbeta bound to compound CHDI-00898647 in the canonical DNA-mismatch bound form · an experimental structure of the same protein · chain A against A, TM-score 0.85
- 2O8F · human MutSalpha (MSH2/MSH6) bound to DNA with a single base T insert · an experimental structure of the same protein · chain A against A, TM-score 0.84
- 2O8F · Human mutsalpha (MSH2/MSH6) bound to DNA with a single base T insert · an experimental structure of the same protein · chain A against A, TM-score 0.84
- 3THY · Human MutSbeta complexed with an IDL of 2 bases (Loop2) and ADP · an experimental structure of the same protein · chain A against A, TM-score 0.84
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P43246
- Elsewhere: UniProt P43246 · AlphaFold DB P43246
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