UniProt P43246
DNA mismatch repair protein Msh2 (P43246)
DNA mismatch repair protein Msh2 (UniProt P43246): 21 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 46 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P43246
- Protein
- DNA mismatch repair protein Msh2
- Experimental structures
- 21
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 46 · 4 records with a druggable one
Structures
22 records of P43246 in the MolNFT archive: 21 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2O8B | human MutSalpha (MSH2/MSH6) bound to ADP and a G T mispair | x-ray diffraction | A | — | — |
| 2O8B | Human mutsalpha (MSH2/MSH6) bound to ADP and a G T mispair | x-ray diffraction | A | — | — |
| 2O8C | human MutSalpha (MSH2/MSH6) bound to ADP and an O6-methyl-guanine T mispair | x-ray diffraction | A | — | — |
| 2O8C | Human mutsalpha (MSH2/MSH6) bound to ADP and an O6-methyl-guanine T mispair | x-ray diffraction | A | — | — |
| 2O8D | human MutSalpha (MSH2/MSH6) bound to ADP and a G dU mispair | x-ray diffraction | A | — | — |
| 2O8D | Human mutsalpha (MSH2/MSH6) bound to ADP and a G du mispair | x-ray diffraction | A | — | — |
| 2O8E | human MutSalpha (MSH2/MSH6) bound to a G T mispair, with ADP bound to MSH2 only | x-ray diffraction | A | — | — |
| 2O8E | Human mutsalpha (MSH2/MSH6) bound to a G T mispair, with ADP bound to MSH2 only | x-ray diffraction | A | — | — |
| 2O8F | human MutSalpha (MSH2/MSH6) bound to DNA with a single base T insert | x-ray diffraction | A | — | — |
| 2O8F | Human mutsalpha (MSH2/MSH6) bound to DNA with a single base T insert | x-ray diffraction | A | — | — |
| 3THW | Human MutSbeta complexed with an IDL of 4 bases (Loop4) and ADP | x-ray diffraction | A | — | — |
| 3THW | Human mutsbeta complexed with an idl of 4 bases (LOOP4) and ADP | x-ray diffraction | A | — | — |
| 3THX | Human MutSbeta complexed with an IDL of 3 bases (Loop3) and ADP | x-ray diffraction | A | — | — |
| 3THX | Human mutsbeta complexed with an idl of 3 bases (LOOP3) and ADP | x-ray diffraction | A | — | — |
| 3THY | Human MutSbeta complexed with an IDL of 2 bases (Loop2) and ADP | x-ray diffraction | A | — | — |
| 3THY | Human mutsbeta complexed with an idl of 2 bases (LOOP2) and ADP | x-ray diffraction | A | — | — |
| 3THZ | Human MutSbeta complexed with an IDL of 6 bases (Loop6) and ADP | x-ray diffraction | A | — | — |
| 3THZ | Human mutsbeta complexed with an idl of 6 bases (LOOP6) and ADP | x-ray diffraction | A | — | — |
| 8OM5 | DNA-free open form of MutSbeta | electron microscopy | A | ADP, MG | 10 (best 0.63) |
| 8OMO | DNA-unbound MutSbeta-ATP complex (bent clamp form) | electron microscopy | A | ATP, MG | 10 (best 0.71) |
| 8R7V | MutSbeta bound to compound CHDI-00898647 in the canonical DNA-mismatch bound form | electron microscopy | A | MG, ADP, YKQ | 15 (best 0.79) |
| P43246 | AlphaFold monomer V2.0 prediction for DNA mismatch repair protein MSH2 (P43246) | predicted | A | — | 11 (best 0.75) |
Ligands
Experiment against prediction
- 2O8E chain A against the predicted model P43246: TM-score 0.96, RMSD 2.18 Å
- 2O8E chain A against the predicted model P43246: TM-score 0.96, RMSD 2.18 Å
- 2O8B chain A against the predicted model P43246: TM-score 0.95, RMSD 2.24 Å
- 2O8B chain A against the predicted model P43246: TM-score 0.95, RMSD 2.24 Å
- 2O8C chain A against the predicted model P43246: TM-score 0.95, RMSD 2.28 Å
- 2O8C chain A against the predicted model P43246: TM-score 0.95, RMSD 2.28 Å
- 2O8D chain A against the predicted model P43246: TM-score 0.95, RMSD 2.30 Å
- 2O8D chain A against the predicted model P43246: TM-score 0.95, RMSD 2.30 Å
- 2O8F chain A against the predicted model P43246: TM-score 0.94, RMSD 2.66 Å
- 2O8F chain A against the predicted model P43246: TM-score 0.94, RMSD 2.66 Å
Elsewhere
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