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Isocitrate dehydrogenase Y160F mutant apo enzyme

Analyse Isocitrate dehydrogenase Y160F mutant apo enzyme in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1IDD
Type: protein
Length: 414 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Isocitrate dehydrogenase
EC: 1.1.1.42
UniProt: P08200
Pockets: 2 · best druggability 0.65

Structure

x-ray diffraction · 1 distinct chain · 41% helix, 19% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Isocitrate dehydrogenase (EC 1.1.1.42)	protein	414	41% helix, 19% strand	P08200

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	443	0.65	0.78	48	empty
2	85	0.39	0.77	20	empty

Compared structures

1IDD · Isocitrate dehydrogenase Y160F mutant apo enzyme · the same entry in another collection · chain A against A, TM-score 1.00
P08200 · AlphaFold monomer V2.0 prediction for isocitrate dehydrogenase [NADP] (P08200) · a predicted model of the same protein · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P08200
Elsewhere: RCSB PDB 1IDD · PDBe 1IDD · UniProt P08200

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