UniProt P08200
Isocitrate dehydrogenase (P08200)
Isocitrate dehydrogenase (UniProt P08200), EC 1.1.1.42: 67 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 6 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P08200
- Protein
- Isocitrate dehydrogenase
- EC
- 1.1.1.42
- Experimental structures
- 67
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 6 · 2 records with a druggable one
Structures
68 records of P08200 in the MolNFT archive: 67 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1AI2 | Isocitrate dehydrogenase complexed with isocitrate, NADP+, and calcium (flash-cooled) | x-ray diffraction | A | — | — |
| 1AI2 | Isocitrate dehydrogenase complexed with isocitrate, NADP+, and calcium (flash-cooled) | x-ray diffraction | A | — | — |
| 1AI3 | Orbital steering in the catalytic power of enzymes: small structural changes with large catalytic… | x-ray diffraction | A | — | — |
| 1AI3 | Orbital steering in the catalytic power of enzymes: small structural changes with large catalytic… | x-ray diffraction | A | — | — |
| 1BL5 | Isocitrate dehydrogenase from E. COLI single turnover laue structure of rate-limited product… | x-ray diffraction | A | — | — |
| 1BL5 | Isocitrate dehydrogenase from E. COLI single turnover laue structure of rate-limited product… | x-ray diffraction | A | — | — |
| 1CW1 | Crystal structure of isocitrate dehydrogenase mutant K230M bound to isocitrate and MN2+ | x-ray diffraction | A | — | — |
| 1CW1 | Crystal structure of isocitrate dehydrogenase mutant K230M bound to isocitrate and MN2+ | x-ray diffraction | A | — | — |
| 1CW4 | Crystal structure of K230M isocitrate dehydrogenase in complex with alpha-ketoglutarate | x-ray diffraction | A | — | — |
| 1CW4 | Crystal structure of K230M isocitrate dehydrogenase in complex with alpha-ketoglutarate | x-ray diffraction | A | — | — |
| 1CW7 | Low temperature structure of wild-type idh complexed with mg-isocitrate | x-ray diffraction | A | — | — |
| 1CW7 | Low temperature structure of wild-type idh complexed with mg- isocitrate | x-ray diffraction | A | — | — |
| 1GRO | Regulatory and catalytic mechanisms in escherichia COLI isocitrate dehydrogenase: multiple roles… | x-ray diffraction | A | — | — |
| 1GRO | Regulatory and catalytic mechanisms in escherichia COLI isocitrate dehydrogenase: multiple roles… | x-ray diffraction | A | — | — |
| 1GRP | Regulatory and catalytic mechanisms in escherichia COLI isocitrate dehydrogenase: multiple roles… | x-ray diffraction | A | — | — |
| 1GRP | Regulatory and catalytic mechanisms in escherichia COLI isocitrate dehydrogenase: multiple roles… | x-ray diffraction | A | — | — |
| 1HJ6 | Isocitrate dehydrogenase S113E mutant complexed with isopropylmalate, NADP+ and magnesium… | x-ray diffraction | A | — | — |
| 1HJ6 | Isocitrate dehydrogenase S113E mutant complexed with isopropylmalate, NADP+ and magnesium… | x-ray diffraction | A | — | — |
| 1IDC | Isocitrate dehydrogenase from E.COLI (mutant K230M), steady-state intermediate complex determined… | x-ray diffraction | A | — | — |
| 1IDC | Isocitrate dehydrogenase from E.COLI (mutant K230M), steady-state intermediate complex determined… | x-ray diffraction | A | — | — |
| 1IDD | Isocitrate dehydrogenase Y160F mutant apo enzyme | x-ray diffraction | A | — | — |
| 1IDD | Isocitrate dehydrogenase Y160F mutant apo enzyme | x-ray diffraction | A | — | — |
| 1IDE | Isocitrate dehydrogenase Y160F mutant steady-state intermediate complex (laue determination) | x-ray diffraction | A | — | — |
| 1IDE | Isocitrate dehydrogenase Y160F mutant steady-state intermediate complex (laue determination) | x-ray diffraction | A | — | — |
| 1IDF | Isocitrate dehydrogenase K230M mutant apo enzyme | x-ray diffraction | A | — | — |
| 1IDF | Isocitrate dehydrogenase K230M mutant apo enzyme | x-ray diffraction | A | — | — |
| 1IKA | Structure of isocitrate dehydrogenase with alpha-ketoglutarate at 2.7 ångströms resolution… | x-ray diffraction | A | — | — |
| 1IKA | Structure of isocitrate dehydrogenase with alpha-ketoglutarate at 2.7 ångströms resolution… | x-ray diffraction | A | — | — |
| 1ISO | Isocitrate dehydrogenase: structure of an engineered NADP+--> NAD+ specificity-reversal mutant | x-ray diffraction | A | — | — |
| 1ISO | Isocitrate dehydrogenase: structure of an engineered NADP+--> NAD+ specificity-reversal mutant | x-ray diffraction | A | — | — |
| 1P8F | A four location model to explain the stereospecificity of proteins. | x-ray diffraction | A | — | — |
| 1P8F | A four location model to explain the stereospecificity of proteins. | x-ray diffraction | A | — | — |
| 1PB1 | A four location model to explain the stereospecificity of proteins. | x-ray diffraction | A | — | — |
| 1PB1 | A four location model to explain the stereospecificity of proteins. | x-ray diffraction | A | — | — |
| 1PB3 | Sites of binding and orientation in a four location model for protein stereospecificity. | x-ray diffraction | A | — | — |
| 1PB3 | Sites of binding and orientation in a four location model for protein stereospecificity. | x-ray diffraction | A | — | — |
| 1SJS | Access to phosphorylation in isocitrate dehydrogenase may occur by domain shifting | x-ray diffraction | A | — | — |
| 1SJS | Access to phosphorylation in isocitrate dehydrogenase may occur by domain shifting | x-ray diffraction | A | — | — |
| 3ICD | Structure of a bacterial enzyme regulated by phosphorylation, isocitrate dehydrogenase | x-ray diffraction | A | — | — |
| 3ICD | Structure of a bacterial enzyme regulated by phosphorylation, isocitrate dehydrogenase | x-ray diffraction | A | — | — |
| 3LCB | The crystal structure of isocitrate dehydrogenase kinase/phosphatase in complex with its substrate… | x-ray diffraction | C, D | — | — |
| 3LCB | The crystal structure of isocitrate dehydrogenase KINASE/PHOSPHATASE in complex with its substrate… | x-ray diffraction | C, D | — | — |
| 4AJ3 | 3D structure of E. coli Isocitrate Dehydrogenase in complex with Isocitrate, calcium(II) and NADP… | x-ray diffraction | A | — | — |
| 4AJ3 | 3D structure of E. COLI isocitrate dehydrogenase in complex with isocitrate, CALCIUM(II) and NADP… | x-ray diffraction | A | — | — |
| 4AJA | 3D structure of E. coli Isocitrate Dehydrogenase in complex with Isocitrate, calcium(II) and… | x-ray diffraction | A | — | — |
| 4AJA | 3D structure of E. COLI isocitrate dehydrogenase in complex with isocitrate, CALCIUM(II) and… | x-ray diffraction | A | — | — |
| 4AJB | 3D structure of E. coli Isocitrate Dehydrogenase K100M mutant in complex with Isocitrate… | x-ray diffraction | A | — | — |
| 4AJB | 3D structure of E. COLI isocitrate dehydrogenase K100M mutant in complex with isocitrate… | x-ray diffraction | A | — | — |
| 4AJR | 3D structure of E. coli Isocitrate Dehydrogenase K100M mutant in complex with alpha-ketoglutarate… | x-ray diffraction | A | — | — |
| 4AJR | 3D structure of E. COLI isocitrate dehydrogenase K100M mutant in complex with alpha-ketoglutarate… | x-ray diffraction | A | — | — |
| 4AJS | 3D structure of E. coli Isocitrate Dehydrogenase K100M mutant in complex with isocitrate… | x-ray diffraction | A | — | — |
| 4AJS | 3D structure of E. COLI isocitrate dehydrogenase K100M mutant in complex with isocitrate… | x-ray diffraction | A | — | — |
| 4BNP | 3D structure of E. coli Isocitrate Dehydrogenase K100M mutant in complex with isocitrate and… | x-ray diffraction | A | — | — |
| 4BNP | 3D structure of E. COLI isocitrate dehydrogenase K100M mutant in complex with isocitrate and… | x-ray diffraction | A | — | — |
| 4ICD | Regulation of isocitrate dehydrogenase by phosphorylation involves no long-range conformational… | x-ray diffraction | A | — | — |
| 4ICD | Regulation of isocitrate dehydrogenase by phosphorylation involves no long-range conformational… | x-ray diffraction | A | — | — |
| 4P69 | Acek (D477A) ICDH complex | x-ray diffraction | C, D | — | — |
| 4P69 | Acek (D477A) icdh complex | x-ray diffraction | C, D | — | — |
| 5ICD | Regulation of an enzyme by phosphorylation at the active site | x-ray diffraction | A | MG, ICT | — |
| 5ICD | Regulation of an enzyme by phosphorylation at the active site | x-ray diffraction | A | — | — |
8 records more on the page itself.
Ligands
Experiment against prediction
- 4AJS chain A against the predicted model P08200: TM-score 1.00, RMSD 0.23 Å
- 4AJS chain A against the predicted model P08200: TM-score 1.00, RMSD 0.23 Å
- 4AJA chain A against the predicted model P08200: TM-score 1.00, RMSD 0.26 Å
- 4AJA chain A against the predicted model P08200: TM-score 1.00, RMSD 0.26 Å
- 1CW1 chain A against the predicted model P08200: TM-score 1.00, RMSD 0.29 Å
- 1CW1 chain A against the predicted model P08200: TM-score 1.00, RMSD 0.29 Å
- 4BNP chain A against the predicted model P08200: TM-score 1.00, RMSD 0.28 Å
- 4BNP chain A against the predicted model P08200: TM-score 1.00, RMSD 0.28 Å
- 4AJB chain A against the predicted model P08200: TM-score 1.00, RMSD 0.29 Å
- 4AJB chain A against the predicted model P08200: TM-score 1.00, RMSD 0.29 Å
Elsewhere
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