Research workbench
Crystal structure of adaptor protein complex 4 (ap-4) MU4 subunit C- terminal domain D190A mutant, in complex with a sorting peptide from the amyloid precursor protein (app)
Analyse Crystal structure of adaptor protein complex 4 (ap-4) MU4 subunit C- terminal… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4MDR
- Type
- protein
- Length
- 252 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ap-4 complex subunit mu-1; Amyloid beta A4 protein
- UniProt
- O00189, P05067
- Pockets
- 1 · best druggability 0.28
Structure
x-ray diffraction · 2 distinct chains · 2% helix, 59% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Ap-4 complex subunit mu-1 | protein | 245 | 2% helix, 60% strand | O00189 |
| B | Amyloid beta A4 protein | protein | 7 | 0% helix, 43% strand | P05067 |
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 60 | 0.28 | 0.74 | 19 | empty |
Interfaces
1 interface between chains.
- A–B · 459 Ų buried · 11 hydrogen bonds · protein-protein
Compared structures
- 4MDR · Crystal structure of adaptor protein complex 4 (AP-4) mu4 subunit C-terminal domain D190A… · the same entry in another collection · chain A against A, TM-score 1.00
- O00189 · AlphaFold monomer V2.0 prediction for ap-4 complex subunit mu-1 (O00189) · a predicted model of the same protein · chain A against A, TM-score 0.97
- P05067 · AlphaFold monomer V2.0 prediction for amyloid-beta precursor protein (P05067) · a predicted model of the same protein · chain B against A, TM-score 0.72
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O00189
- Every structure of UniProt P05067
- Elsewhere: RCSB PDB 4MDR · PDBe 4MDR · UniProt O00189 · UniProt P05067
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.