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Crystal structure of anti-tissue factor antibody 10H10

Analyse Crystal structure of anti-tissue factor antibody 10H10 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4M7K
Type: protein
Length: 449 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: 10H10 light chain; 10H10 heavy chain
Ligands: CA
Pockets: 5 · best druggability 0.56

Structure

x-ray diffraction · 2 distinct chains · 8% helix, 50% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
L	10H10 light chain	protein	220	5% helix, 51% strand	—
H	10H10 heavy chain	protein	229	10% helix, 48% strand	—

Ligands and binding sites

CA · Calcium ion · metal · chains H
ACT · Acetate ion · additive · chains H

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	420	0.56	0.74	57	empty
2	67	0.38	0.79	15	empty
3	109	0.38	0.75	19	empty
4	80	0.32	0.73	20	empty
5	53	0.29	0.75	13	empty

Interfaces

1 interface between chains.

L–H · 2203 Å² buried · 25 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 5 disulfide, 1 modified (disulfide, cyclization).

Compared structures

4M7K · Crystal structure of anti-tissue factor antibody 10H10 · the same entry in another collection · chain L against L, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 4M7K · PDBe 4M7K

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