Research workbench
Hepatocyte nuclear factor 1A bound to DNA : MODY3 gene product
Analyse Hepatocyte nuclear factor 1A bound to DNA : MODY3 gene product in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1IC8
- Type
- protein + DNA
- Length
- 385 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 5'-D(*CP*TP*TP*GP*GP*TP*TP*AP*AP*TP*AP*AP*TP*TP*CP*AP*CP*CP *AP*GP*A)-3'…
- UniProt
- P20823
- Pockets
- 8 · best druggability 0.73
Structure
x-ray diffraction · 4 distinct chains · 62% helix, 1% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| E | 5'-D(*CP*TP*TP*GP*GP*TP*TP*AP*AP*TP*AP*AP*TP*TP*CP*AP*CP*CP *AP*GP*A)-3' | dna | 21 | — | — |
| F | 5'-D(*TP*CP*TP*GP*GP*TP*GP*AP*AP*TP*TP*AP*TP*TP*AP*AP*CP*CP *AP*AP*G)-3' | dna | 21 | — | — |
| A | Hepatocyte nuclear factor 1-alpha | protein | 170 | 64% helix, 1% strand | P20823 |
| B | Hepatocyte nuclear factor 1-alpha | protein | 173 | 61% helix, 1% strand | P20823 |
Pockets
8 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 595 | 0.73 | 0.81 | 59 | empty |
| 2 | 305 | 0.69 | 0.84 | 33 | empty |
| 3 | 180 | 0.61 | 0.83 | 23 | empty |
| 4 | 86 | 0.48 | 0.83 | 17 | empty |
| 5 | 85 | 0.46 | 0.82 | 17 | empty |
Interfaces
6 interfaces between chains.
- E–F · 909 Ų buried · 87 hydrogen bonds · nucleic-nucleic
- E–B · 719 Ų buried · 15 hydrogen bonds · protein-nucleic
- E–A · 697 Ų buried · 13 hydrogen bonds · protein-nucleic
- F–A · 670 Ų buried · 13 hydrogen bonds · protein-nucleic
- F–B · 670 Ų buried · 17 hydrogen bonds · protein-nucleic
Compared structures
- 1IC8 · Hepatocyte nuclear factor 1A bound to DNA : MODY3 gene product · the same entry in another collection · chain E against E, TM-score 1.00
- P20823 · AlphaFold monomer V2.0 prediction for hepatocyte nuclear factor 1-alpha (P20823) · a predicted model of the same protein · chain A against A, TM-score 0.94
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P20823
- Elsewhere: RCSB PDB 1IC8 · PDBe 1IC8 · UniProt P20823
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.