UniProt P20823
Hepatocyte nuclear factor 1-alpha (P20823)
Hepatocyte nuclear factor 1-alpha (UniProt P20823): 5 experimental structures and 1 predicted model on GenesisL1, 11 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P20823
- Protein
- Hepatocyte nuclear factor 1-alpha
- Experimental structures
- 5
- Predicted models
- 1
- Pockets
- 11 · 2 records with a druggable one
Structures
6 records of P20823 in the MolNFT archive: 5 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1IC8 | Hepatocyte nuclear factor 1A bound to DNA : MODY3 gene product | x-ray diffraction | A, B | — | — |
| 1IC8 | Hepatocyte nuclear factor 1A bound to DNA : MODY3 gene product | x-ray diffraction | A, B | — | — |
| 2GYP | Diabetes mellitus due to a frustrated Schellman motif in HNF-1a | x-ray diffraction | A, B | — | — |
| 2GYP | Diabetes mellitus due to a frustrated schellman motif in hnf-1A | x-ray diffraction | A, B | — | — |
| 8PIA | DNA binding domain of HNF-1A bound to P2-HNF4A promoter DNA variant (P2 -181G>T) | x-ray diffraction | A, B | — | 10 (best 0.69) |
| P20823 | AlphaFold monomer V2.0 prediction for hepatocyte nuclear factor 1-alpha (P20823) | predicted | A | — | 1 (best 0.53) |
Experiment against prediction
- 8PIA chain B against the predicted model P20823: TM-score 0.99, RMSD 0.55 Å
- 8PIA chain A against the predicted model P20823: TM-score 0.99, RMSD 0.56 Å
- 1IC8 chain A against the predicted model P20823: TM-score 0.94, RMSD 1.21 Å
- 1IC8 chain A against the predicted model P20823: TM-score 0.94, RMSD 1.21 Å
- 1IC8 chain B against the predicted model P20823: TM-score 0.92, RMSD 1.27 Å
- 1IC8 chain B against the predicted model P20823: TM-score 0.92, RMSD 1.27 Å
- 2GYP chain A against the predicted model P20823: TM-score 0.53, RMSD 2.55 Å
- 2GYP chain A against the predicted model P20823: TM-score 0.53, RMSD 2.55 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.