Research workbench
Gamma subunit of the translation initiation factor 2 from sulfolobus solfataricus in nucleotide-free form
Analyse Gamma subunit of the translation initiation factor 2 from sulfolobus… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4M2L
- Type
- protein
- Length
- 398 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Translation initiation factor 2 subunit gamma
- UniProt
- Q980A5
- Ligands
- SO4, PO4
- Pockets
- 5 · best druggability 0.62
Structure
x-ray diffraction · 1 distinct chain · 18% helix, 41% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Translation initiation factor 2 subunit gamma | protein | 398 | 18% helix, 41% strand | Q980A5 |
Ligands and binding sites
- SO4 · Sulfate ion · ion · 4 copies · chains A
- PO4 · Phosphate ion · ion · 4 copies · chains A
- EDO · 1,2-ethanediol · additive · 27 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 376 | 0.62 | 0.78 | 39 | EDO |
| 2 | 220 | 0.57 | 0.79 | 32 | empty |
| 3 | 99 | 0.39 | 0.76 | 26 | PO4, EDO |
| 4 | 105 | 0.36 | 0.74 | 15 | empty |
| 5 | 58 | 0.30 | 0.75 | 15 | EDO |
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
- 4M2L · Gamma subunit of the translation initiation factor 2 from Sulfolobus solfataricus in… · the same entry in another collection · chain A against A, TM-score 1.00
- Q980A5 · AlphaFold monomer V2.0 prediction for translation initiation factor 2 subunit gamma… · a predicted model of the same protein · chain A against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q980A5
- Elsewhere: RCSB PDB 4M2L · PDBe 4M2L · UniProt Q980A5
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