Binary complex of human DNA polymerase mu with DNA

Structure

x-ray diffraction · 4 distinct chains · 52% helix, 14% strand (DSSP).

Ligands and binding sites

• NA · Sodium ion · metal · 2 copies · chains A, P
• CL · Chloride ion · ion · 2 copies · chains A, D, T
• GOL · Glycerol · additive · chains A, T, P

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Interfaces

5 interfaces between chains.

• A–T · 718 Ų buried · 16 hydrogen bonds · protein-nucleic
• A–D · 396 Ų buried · 17 hydrogen bonds · protein-nucleic
• A–P · 395 Ų buried · 9 hydrogen bonds · protein-nucleic
• T–P · 226 Ų buried · 15 hydrogen bonds · nucleic-nucleic
• T–D · 196 Ų buried · 15 hydrogen bonds · nucleic-nucleic

Compared structures

• 4LZG · Binary complex of human DNA Polymerase Mu with DNA · the same entry in another collection · chain A against A, TM-score 1.00
• Q9NP87 · AlphaFold monomer V2.0 prediction for DNA-directed DNA/RNA polymerase mu (Q9NP87) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt Q9NP87
• Elsewhere: RCSB PDB 4LZG · PDBe 4LZG · UniProt Q9NP87