Research workbench
Cytoplasmic domain of unphosphorylated type I TGF-beta receptor crystallized without FKBP12
Analyse Cytoplasmic domain of unphosphorylated type I TGF-beta receptor crystallized… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1IAS
- Type
- protein
- Length
- 1,644 residues
- Chains
- 5
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- TGF-beta receptor type I
- EC
- 2.7.1.37
- UniProt
- P36897
- Ligands
- SO4
- Pockets
- 20 · best druggability 0.73
Structure
x-ray diffraction · 2 distinct chains · 43% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C, D, E | TGF-beta receptor type I (EC 2.7.1.37) | protein | 330 | 42% helix, 17% strand | P36897 |
| B | TGF-beta receptor type I (EC 2.7.1.37) | protein | 324 | 43% helix, 17% strand | P36897 |
Ligands and binding sites
- SO4 · Sulfate ion · ion · 15 copies · chains E, C, B, A, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 19 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 70 | 0.73 | 0.97 | 19 | empty |
| 2 | 73 | 0.73 | 0.97 | 19 | empty |
| 3 | 63 | 0.73 | 0.98 | 18 | empty |
| 4 | 238 | 0.73 | 0.87 | 35 | empty |
| 5 | 80 | 0.72 | 0.96 | 21 | empty |
Interfaces
5 interfaces between chains.
- D–E · 631 Ų buried · 4 hydrogen bonds · protein-protein
- B–C · 614 Ų buried · 3 hydrogen bonds · protein-protein
- C–E · 574 Ų buried · 4 hydrogen bonds · protein-protein
- A–B · 569 Ų buried · 4 hydrogen bonds · protein-protein
- A–D · 565 Ų buried · 5 hydrogen bonds · protein-protein
Compared structures
- 1IAS · Cytoplasmic domain of unphosphorylated type I TGF-beta receptor crystallized without… · the same entry in another collection · chain B against B, TM-score 1.00
- P36897 · AlphaFold monomer V2.0 prediction for TGF-beta receptor type-1 (P36897) · a predicted model of the same protein · chain B against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P36897
- Elsewhere: RCSB PDB 1IAS · PDBe 1IAS · UniProt P36897
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