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Crystal structure of P115RHOGEF rgrgs domain

Analyse Crystal structure of P115RHOGEF rgrgs domain in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1IAP
Type: protein
Length: 190 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Guanine nucleotide exchange factor P115RHOGEF
UniProt: Q92888
Pockets: 2 · best druggability 0.36

Structure

x-ray diffraction · 1 distinct chain · 69% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Guanine nucleotide exchange factor P115RHOGEF	protein	190	69% helix, 0% strand	Q92888

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	77	0.36	0.76	16	empty
2	74	0.32	0.74	18	empty

Compared structures

1IAP · Crystal structure of P115RHOGEF rgrgs domain · the same entry in another collection · chain A against A, TM-score 1.00
Q92888 · AlphaFold monomer V2.0 prediction for rho guanine nucleotide exchange factor 1 (Q92888) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q92888
Elsewhere: RCSB PDB 1IAP · PDBe 1IAP · UniProt Q92888

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