MolNFT v1 · #22618 · protein
AlphaFold monomer V2.0 prediction for rho guanine nucleotide exchange factor 1 (Q92888)
Q92888: “AlphaFold monomer V2.0 prediction for rho guanine nucleotide exchange factor 1 (Q92888)”. 10 pockets (best druggability 0.77). MolNFT v1 #22618 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- Q92888
- Type
- protein
- Length
- 912 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0xf97f120f1cAC0985138AF468D0d17B7b3f67FB36
- Molecule
- Rho guanine nucleotide exchange factor 1
- UniProt
- Q92888
- Pockets
- 10 · best druggability 0.77
Structure
1 distinct chain · 47% helix, 7% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Rho guanine nucleotide exchange factor 1 | protein | 912 | 47% helix, 7% strand | Q92888 |
Pockets
10 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 963 | 0.77 | 0.79 | 66 | empty |
| 2 | 261 | 0.54 | 0.76 | 33 | empty |
| 3 | 306 | 0.54 | 0.75 | 33 | empty |
| 4 | 116 | 0.45 | 0.78 | 22 | empty |
| 5 | 55 | 0.34 | 0.78 | 14 | empty |
Compared structures
- 3ODO · Crystal structure of the DH/PH domains of P115-rhogef · an experimental structure of the same protein · chain A against B, TM-score 0.40
- 3ODO · Crystal Structure of the DH/PH Domains of p115-RhoGEF · an experimental structure of the same protein · chain A against B, TM-score 0.40
- 3P6A · Crystal Structure of the DH/PH domains of p115-RhoGEF (R399E mutant) · an experimental structure of the same protein · chain A against A, TM-score 0.36
- 3P6A · Crystal structure of the DH/PH domains of P115-rhogef (R399E mutant) · an experimental structure of the same protein · chain A against A, TM-score 0.36
- 3ODX · Crystal structure of an N-terminally truncated linker-DH/PH domains of P115-rhogef · an experimental structure of the same protein · chain A against A, TM-score 0.36
- 3ODX · Crystal Structure of an N-terminally Truncated Linker-DH/PH Domains of p115-RhoGEF · an experimental structure of the same protein · chain A against A, TM-score 0.36
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q92888
- Elsewhere: UniProt Q92888 · AlphaFold DB Q92888
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