MolNFT v1 · #74763 · protein
Crystal structure of the DH/PH domains of P115-rhogef (R399E mutant)
3P6A · Rho guanine nucleotide exchange factor 1: “Crystal structure of the DH/PH domains of P115-rhogef (R399E mutant)”. X-ray diffraction, 6 pockets (best druggability 0.57). MolNFT v1 #74763 on GenesisL1: 3D structure, binding sites and…
- PDB
- 3P6A
- Type
- protein
- Length
- 687 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Rho guanine nucleotide exchange factor 1
- UniProt
- Q92888
- Pockets
- 6 · best druggability 0.57
Structure
x-ray diffraction · 2 distinct chains · 60% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Rho guanine nucleotide exchange factor 1 | protein | 344 | 60% helix, 15% strand | Q92888 |
| B | Rho guanine nucleotide exchange factor 1 | protein | 343 | 60% helix, 16% strand | Q92888 |
Pockets
6 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 161 | 0.57 | 0.82 | 25 | empty |
| 2 | 79 | 0.57 | 0.87 | 13 | empty |
| 3 | 158 | 0.49 | 0.78 | 20 | empty |
| 4 | 109 | 0.40 | 0.76 | 16 | empty |
| 5 | 69 | 0.34 | 0.76 | 15 | empty |
Interfaces
1 interface between chains.
- A–B · 999 Ų buried · 14 hydrogen bonds · protein-protein
Compared structures
- 3P6A · Crystal Structure of the DH/PH domains of p115-RhoGEF (R399E mutant) · the same entry in another collection · chain A against A, TM-score 1.00
- Q92888 · AlphaFold monomer V2.0 prediction for rho guanine nucleotide exchange factor 1 (Q92888) · a predicted model of the same protein · chain B against A, TM-score 0.91
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q92888
- Elsewhere: RCSB PDB 3P6A · PDBe 3P6A · UniProt Q92888
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