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Mycobacterium tuberculosis L-alanine dehydrogenase X-ray structure in complex with N6-methyl adenosine

Analyse Mycobacterium tuberculosis L-alanine dehydrogenase X-ray structure in complex… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4LMP
Type: protein
Length: 371 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Alanine dehydrogenase
EC: 1.4.1.1
UniProt: I6YEC9
Ligands: 6MD, SO4
Pockets: 1 · best druggability 0.74

Structure

x-ray diffraction · 1 distinct chain · 42% helix, 18% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Alanine dehydrogenase (EC 1.4.1.1)	protein	371	42% helix, 18% strand	I6YEC9

Ligands and binding sites

6MD · N-methyladenosine · ligand · chains A
SO4 · Sulfate ion · ion · 3 copies · chains A
GOL · Glycerol · additive · 4 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	496	0.74	0.82	72	6MD, GOL, SO4

Compared structures

4LMP · Mycobacterium tuberculosis L-alanine dehydrogenase x-ray structure in complex with… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt I6YEC9
Elsewhere: RCSB PDB 4LMP · PDBe 4LMP · UniProt I6YEC9

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