Research workbench
Glic double mutant I9'A T25'A
Analyse Glic double mutant I9'A T25'A in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4LML
- Type
- protein
- Length
- 1,550 residues
- Chains
- 5
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Proton-gated ion channel
- UniProt
- Q7NDN8
- Pockets
- 20 · best druggability 0.79
Structure
x-ray diffraction · 1 distinct chain · 35% helix, 32% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E | Proton-gated ion channel | protein | 310 | 35% helix, 32% strand | Q7NDN8 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1103 | 0.79 | 0.80 | 71 | empty |
| 2 | 111 | 0.75 | 0.95 | 20 | empty |
| 3 | 93 | 0.74 | 0.96 | 20 | empty |
| 4 | 82 | 0.73 | 0.96 | 19 | empty |
| 5 | 147 | 0.71 | 0.90 | 33 | empty |
Interfaces
9 interfaces between chains.
- A–C · 2217 Ų buried · 9 hydrogen bonds · protein-protein
- B–C · 2206 Ų buried · 12 hydrogen bonds · protein-protein
- D–E · 2202 Ų buried · 8 hydrogen bonds · protein-protein
- A–D · 2167 Ų buried · 10 hydrogen bonds · protein-protein
- B–E · 2135 Ų buried · 13 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q7NDN8
- Elsewhere: RCSB PDB 4LML · PDBe 4LML · UniProt Q7NDN8
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