Research workbench

ANNEXIN IV

Analyse ANNEXIN IV in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1ANN
Type: protein
Length: 315 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Annexin IV
UniProt: P13214
Ligands: CA
Pockets: 3 · best druggability 0.55

Structure

x-ray diffraction · 1 distinct chain · 73% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Annexin IV	protein	315	73% helix, 0% strand	P13214

Ligands and binding sites

CA · Calcium ion · metal · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	90	0.55	0.85	23	empty
2	120	0.50	0.80	26	empty
3	89	0.45	0.80	14	empty

Compared structures

1ANN · ANNEXIN IV · the same entry in another collection · chain A against A, TM-score 1.00
P13214 · AlphaFold monomer V2.0 prediction for annexin A4 (P13214) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P13214
Elsewhere: RCSB PDB 1ANN · PDBe 1ANN · UniProt P13214

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